Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway

Eosinophils and pleural macrophages counter regulate IL-33-elicited airway inflammation via the 12/15-lipoxygenase pathway

IntroductionFatty acid metabolism plays a crucial role in regulating airway inflammation through the synthesis of lipid mediators. We have previously demonstrated that a 12/15-lipoxygenase (12/15-LOX or Alox15)-derived mediator attenuates IL-33-induced eosinophilic airway inflammation in mice. Howev...

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Bibliographic Details
Main Authors: Emi Ito, Reika Hayashizaki, Takuro Hosaka, Tsuyoshi Yamane, Jun Miyata, Yosuke Isobe, Makoto Arita
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
eosinophils
pleural macrophages
12/15-lipoxygenase
IL-33
lipidomics
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565670/full
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