Global prevalence of dyslipidaemia in adult populations: a systematic review protocol
Introduction Dyslipidaemia is one of the established risk factors for cardiovascular disease. Evidence from large-scale trials showed that effective treatment of dyslipidaemia can reduce all-cause and coronary mortality. To date, there is no published systematic review on the worldwide prevalence of...
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BMJ Publishing Group
2021-12-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/11/12/e049662.full |
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| author | Mohamed-Syarif Mohamed-Yassin Noorhida Baharudin Suraya Abdul-Razak Anis Safura Ramli Nai Ming Lai |
| author_facet | Mohamed-Syarif Mohamed-Yassin Noorhida Baharudin Suraya Abdul-Razak Anis Safura Ramli Nai Ming Lai |
| author_sort | Mohamed-Syarif Mohamed-Yassin |
| collection | DOAJ |
| description | Introduction Dyslipidaemia is one of the established risk factors for cardiovascular disease. Evidence from large-scale trials showed that effective treatment of dyslipidaemia can reduce all-cause and coronary mortality. To date, there is no published systematic review on the worldwide prevalence of dyslipidaemia in adults. We propose to perform a systematic review on the global prevalence of dyslipidaemia in adults 18 years and older.Methods and analysis We will identify observational studies through comprehensive literature searches. We will search: MEDLINE, Cochrane Central Register of Controlled Trials for published studies and trial registries including the WHO International Trial Registry Platform and ClinicalTrials.gov. Two reviewers will independently screen the titles and abstracts, attain full text of eligible articles, extract data, and appraise the quality and bias of the included studies. Disagreement among the authors will be resolved by discussion leading to a consensus. Next, we will perform a narrative synthesis of the study results. Study heterogeneity will be assessed using I2 statistics. If I2 is high (≥75%), and plausible heterogeneity contributors are found, we will divide the studies into appropriate subgroups for pooling of results or assess the association of plausible covariates and the prevalence estimates using meta-regression. If I2<75%, we will undertake meta-analysis using the random-effects model and transform all prevalence estimates using the Freeman-Tukey transformation for pooling, to obtain a synthesised point estimate of prevalence with its 95% confidence. We will then back-transform the point estimate, and report our results using the back-transformed figures.Ethics and dissemination Ethics approval is not a requirement as this study is based on available published data. Results of this systematic review will be presented at conferences, shared with relevant health authorities, and published in a peer-reviewed journal. These results may help quantify the magnitude of dyslipidaemia globally, and guide preventative and therapeutic interventions.PROSPERO registration number CRD42020200281 |
| format | Article |
| id | doaj-art-0ed52c316e0d46558419eb235a97e38a |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2021-12-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-0ed52c316e0d46558419eb235a97e38a2024-12-09T20:15:13ZengBMJ Publishing GroupBMJ Open2044-60552021-12-01111210.1136/bmjopen-2021-049662Global prevalence of dyslipidaemia in adult populations: a systematic review protocolMohamed-Syarif Mohamed-Yassin0Noorhida Baharudin1Suraya Abdul-Razak2Anis Safura Ramli3Nai Ming Lai4Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, MalaysiaDepartment of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, MalaysiaDepartment of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, MalaysiaDepartment of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, MalaysiaDigital Health and Innovation Impact Lab, Taylor`s University, Subang Jaya, MalaysiaIntroduction Dyslipidaemia is one of the established risk factors for cardiovascular disease. Evidence from large-scale trials showed that effective treatment of dyslipidaemia can reduce all-cause and coronary mortality. To date, there is no published systematic review on the worldwide prevalence of dyslipidaemia in adults. We propose to perform a systematic review on the global prevalence of dyslipidaemia in adults 18 years and older.Methods and analysis We will identify observational studies through comprehensive literature searches. We will search: MEDLINE, Cochrane Central Register of Controlled Trials for published studies and trial registries including the WHO International Trial Registry Platform and ClinicalTrials.gov. Two reviewers will independently screen the titles and abstracts, attain full text of eligible articles, extract data, and appraise the quality and bias of the included studies. Disagreement among the authors will be resolved by discussion leading to a consensus. Next, we will perform a narrative synthesis of the study results. Study heterogeneity will be assessed using I2 statistics. If I2 is high (≥75%), and plausible heterogeneity contributors are found, we will divide the studies into appropriate subgroups for pooling of results or assess the association of plausible covariates and the prevalence estimates using meta-regression. If I2<75%, we will undertake meta-analysis using the random-effects model and transform all prevalence estimates using the Freeman-Tukey transformation for pooling, to obtain a synthesised point estimate of prevalence with its 95% confidence. We will then back-transform the point estimate, and report our results using the back-transformed figures.Ethics and dissemination Ethics approval is not a requirement as this study is based on available published data. Results of this systematic review will be presented at conferences, shared with relevant health authorities, and published in a peer-reviewed journal. These results may help quantify the magnitude of dyslipidaemia globally, and guide preventative and therapeutic interventions.PROSPERO registration number CRD42020200281https://bmjopen.bmj.com/content/11/12/e049662.full |
| spellingShingle | Mohamed-Syarif Mohamed-Yassin Noorhida Baharudin Suraya Abdul-Razak Anis Safura Ramli Nai Ming Lai Global prevalence of dyslipidaemia in adult populations: a systematic review protocol BMJ Open |
| title | Global prevalence of dyslipidaemia in adult populations: a systematic review protocol |
| title_full | Global prevalence of dyslipidaemia in adult populations: a systematic review protocol |
| title_fullStr | Global prevalence of dyslipidaemia in adult populations: a systematic review protocol |
| title_full_unstemmed | Global prevalence of dyslipidaemia in adult populations: a systematic review protocol |
| title_short | Global prevalence of dyslipidaemia in adult populations: a systematic review protocol |
| title_sort | global prevalence of dyslipidaemia in adult populations a systematic review protocol |
| url | https://bmjopen.bmj.com/content/11/12/e049662.full |
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