Deciphering spatial domains from spatially resolved transcriptomics through spatially regularized deep graph networks

Deciphering spatial domains from spatially resolved transcriptomics through spatially regularized deep graph networks

Abstract Background Recent advancements in spatially resolved transcriptomics (SRT) have opened up unprecedented opportunities to explore gene expression patterns within spatial contexts. Deciphering spatial domains is a critical task in spatial transcriptomic data analysis, aiding in the elucidatio...

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Bibliographic Details
Main Authors: Daoliang Zhang, Na Yu, Xue Sun, Haoyang Li, Wenjing Zhang, Xu Qiao, Wei Zhang, Rui Gao
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Genomics
Subjects:
Spatial resolved transcriptomics
Graph attention network
Spatial regularization constraint
Cross-entropy loss
Spatial domains
Online Access:https://doi.org/10.1186/s12864-024-11072-w
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