Liquid biopsy, big data and artificial intelligence as a new global clinical trial model in targeted therapy
To this day, the phase III trial continues to be, as it was more than 60 years ago, the standard for the incorporation of new treatments in oncology. We currently have new tools such as NGS, Liquid Biopsy (LB), Big Data (BD) and Artificial Intelligence (AI) that will allow us to move towards faster...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-09-01
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| Series: | The Journal of Liquid Biopsy |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950195423000085 |
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| author | Albert Abad Joana Vidal Laura Layos Cesar Morcillo Izar Achaerandio Santiago Viteri |
| author_facet | Albert Abad Joana Vidal Laura Layos Cesar Morcillo Izar Achaerandio Santiago Viteri |
| author_sort | Albert Abad |
| collection | DOAJ |
| description | To this day, the phase III trial continues to be, as it was more than 60 years ago, the standard for the incorporation of new treatments in oncology. We currently have new tools such as NGS, Liquid Biopsy (LB), Big Data (BD) and Artificial Intelligence (AI) that will allow us to move towards faster and more universal research. This article analyzes the important weaknesses of phase III trials, the importance and current status of targeted therapy, and the contributions to LB decision-making and the knowledge of what happens in real life (RWD) that we facilitates BD and AI. Finally, what could be a clinical trial model that would take advantage of all these tools is proposed. |
| format | Article |
| id | doaj-art-0eca988e0e7d433fb838abaf6ffc7f3f |
| institution | Kabale University |
| issn | 2950-1954 |
| language | English |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | The Journal of Liquid Biopsy |
| spelling | doaj-art-0eca988e0e7d433fb838abaf6ffc7f3f2024-11-22T07:40:58ZengElsevierThe Journal of Liquid Biopsy2950-19542023-09-011100008Liquid biopsy, big data and artificial intelligence as a new global clinical trial model in targeted therapyAlbert Abad0Joana Vidal1Laura Layos2Cesar Morcillo3Izar Achaerandio4Santiago Viteri5UOMI Cancer Center, MiTres Torres, Barcelona, Spain; Corresponding author. UOMI Cancer Center, MiTres Torres, C/ Doctor Roux 76, 08017 Barcelona. Spain.Medical Oncology Department, Hospital del Mar Research Institute, CIBERONC, Barcelona, SpainMedical Oncology Department, Catalan Institute of Oncology (ICO) Applied Research Group in Oncology (B-ARGO), Germans Trias i Pujol University Hospital, Badalona, Barcelona, SpainHospital Digital, Hospital Sanitas CIMA, Barcelona, SpainInstitut Clinic de Malalties Hemato-Oncologiques, Hospital Clinic, Barcelona, SpainUOMI Cancer Center, MiTres Torres, Barcelona, SpainTo this day, the phase III trial continues to be, as it was more than 60 years ago, the standard for the incorporation of new treatments in oncology. We currently have new tools such as NGS, Liquid Biopsy (LB), Big Data (BD) and Artificial Intelligence (AI) that will allow us to move towards faster and more universal research. This article analyzes the important weaknesses of phase III trials, the importance and current status of targeted therapy, and the contributions to LB decision-making and the knowledge of what happens in real life (RWD) that we facilitates BD and AI. Finally, what could be a clinical trial model that would take advantage of all these tools is proposed.http://www.sciencedirect.com/science/article/pii/S2950195423000085Liquid biopsyFase IIITargeted therapyBig dataArtificial intelligence |
| spellingShingle | Albert Abad Joana Vidal Laura Layos Cesar Morcillo Izar Achaerandio Santiago Viteri Liquid biopsy, big data and artificial intelligence as a new global clinical trial model in targeted therapy The Journal of Liquid Biopsy Liquid biopsy Fase III Targeted therapy Big data Artificial intelligence |
| title | Liquid biopsy, big data and artificial intelligence as a new global clinical trial model in targeted therapy |
| title_full | Liquid biopsy, big data and artificial intelligence as a new global clinical trial model in targeted therapy |
| title_fullStr | Liquid biopsy, big data and artificial intelligence as a new global clinical trial model in targeted therapy |
| title_full_unstemmed | Liquid biopsy, big data and artificial intelligence as a new global clinical trial model in targeted therapy |
| title_short | Liquid biopsy, big data and artificial intelligence as a new global clinical trial model in targeted therapy |
| title_sort | liquid biopsy big data and artificial intelligence as a new global clinical trial model in targeted therapy |
| topic | Liquid biopsy Fase III Targeted therapy Big data Artificial intelligence |
| url | http://www.sciencedirect.com/science/article/pii/S2950195423000085 |
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