Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study
ABSTRACT Introduction While type 2 diabetes (T2DM) has become a major health issue in the North American and Caribbean region, the effects of weight change on incident T2DM, conditional on either initial or attained weight, are poorly addressed. Therefore, we aimed to assess the impact of 3‐year wei...
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Wiley
2025-05-01
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| Series: | Endocrinology, Diabetes & Metabolism |
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| Online Access: | https://doi.org/10.1002/edm2.70040 |
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| author | Samaneh Asgari Soroush Masrouri Davood Khalili Mojtaba Lotfaliany Farzad Hadaegh |
| author_facet | Samaneh Asgari Soroush Masrouri Davood Khalili Mojtaba Lotfaliany Farzad Hadaegh |
| author_sort | Samaneh Asgari |
| collection | DOAJ |
| description | ABSTRACT Introduction While type 2 diabetes (T2DM) has become a major health issue in the North American and Caribbean region, the effects of weight change on incident T2DM, conditional on either initial or attained weight, are poorly addressed. Therefore, we aimed to assess the impact of 3‐year weight change on incident T2DM over 6 years among US individuals. Methods A total of 8377 participants aged 45–64 years (4601 women), free of T2DM or cancer at baseline from the Atherosclerosis Risk in Communities (ARIC) study were included. Weight measurements were taken at baseline (visit 1, 1987–89) and approximately 3 years later (visit 2, 1990–92). Participants were categorised based on their weight change ratio into ≥ 5% weight loss, stable (±5%), and ≥ 5% weight gain. Cox proportional hazards models, adjusting for known diabetes risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident T2DM, with stable weight (±5%) as the reference category. Results During a median follow‐up period of 6 years, participants were classified into three categories: 361 persons remained stable (±5%), 47 with ≥ 5% loss, and 135 with ≥ 5% gain. In multivariable analysis, after adjustment with initial weight, ≥ 5% weight gain and loss were significantly associated with higher [HR (95% CI): 1.68 (1.36–2.06), p‐value < 0.0001] and lower [0.73 (0.53–1.00), p‐value = 0.05] risks of incident T2DM, respectively. When adjusted for attained weight, weight gain ≥ 5% remained a significant risk factor for T2DM [1.51 (1.21–1.88)]; however, weight loss ≥ 5% lost statistical significance [0.84 (0.60–1.17), p‐value = 0.31]. Conclusions We found a robust association between weight gain and incident T2DM; however, the beneficial impact of weight loss was significantly attenuated after considering the attained weight. |
| format | Article |
| id | doaj-art-0ec8223e0e934c74b88cdf7a4c2a8d7d |
| institution | Kabale University |
| issn | 2398-9238 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Endocrinology, Diabetes & Metabolism |
| spelling | doaj-art-0ec8223e0e934c74b88cdf7a4c2a8d7d2025-08-20T03:48:15ZengWileyEndocrinology, Diabetes & Metabolism2398-92382025-05-0183n/an/a10.1002/edm2.70040Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) StudySamaneh Asgari0Soroush Masrouri1Davood Khalili2Mojtaba Lotfaliany3Farzad Hadaegh4Prevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran IranPrevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran IranPrevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran IranIMPACT, The Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Barwon Health Deakin University Geelong AustraliaPrevention of Metabolic Disorders Research Center, Research Institute for Metabolic and Obesity Disorders, Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran IranABSTRACT Introduction While type 2 diabetes (T2DM) has become a major health issue in the North American and Caribbean region, the effects of weight change on incident T2DM, conditional on either initial or attained weight, are poorly addressed. Therefore, we aimed to assess the impact of 3‐year weight change on incident T2DM over 6 years among US individuals. Methods A total of 8377 participants aged 45–64 years (4601 women), free of T2DM or cancer at baseline from the Atherosclerosis Risk in Communities (ARIC) study were included. Weight measurements were taken at baseline (visit 1, 1987–89) and approximately 3 years later (visit 2, 1990–92). Participants were categorised based on their weight change ratio into ≥ 5% weight loss, stable (±5%), and ≥ 5% weight gain. Cox proportional hazards models, adjusting for known diabetes risk factors, were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of incident T2DM, with stable weight (±5%) as the reference category. Results During a median follow‐up period of 6 years, participants were classified into three categories: 361 persons remained stable (±5%), 47 with ≥ 5% loss, and 135 with ≥ 5% gain. In multivariable analysis, after adjustment with initial weight, ≥ 5% weight gain and loss were significantly associated with higher [HR (95% CI): 1.68 (1.36–2.06), p‐value < 0.0001] and lower [0.73 (0.53–1.00), p‐value = 0.05] risks of incident T2DM, respectively. When adjusted for attained weight, weight gain ≥ 5% remained a significant risk factor for T2DM [1.51 (1.21–1.88)]; however, weight loss ≥ 5% lost statistical significance [0.84 (0.60–1.17), p‐value = 0.31]. Conclusions We found a robust association between weight gain and incident T2DM; however, the beneficial impact of weight loss was significantly attenuated after considering the attained weight.https://doi.org/10.1002/edm2.70040atherosclerosis risk in communities studyincidenttype 2 diabetesweight gainweight loss |
| spellingShingle | Samaneh Asgari Soroush Masrouri Davood Khalili Mojtaba Lotfaliany Farzad Hadaegh Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study Endocrinology, Diabetes & Metabolism atherosclerosis risk in communities study incident type 2 diabetes weight gain weight loss |
| title | Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study |
| title_full | Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study |
| title_fullStr | Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study |
| title_full_unstemmed | Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study |
| title_short | Weight Gain, Weight Loss, and Type 2 Diabetes Risk: Evidence From the Atherosclerosis Risk in Communities (ARIC) Study |
| title_sort | weight gain weight loss and type 2 diabetes risk evidence from the atherosclerosis risk in communities aric study |
| topic | atherosclerosis risk in communities study incident type 2 diabetes weight gain weight loss |
| url | https://doi.org/10.1002/edm2.70040 |
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