Fibrosis in PCLS: comparing TGF-β and fibrotic cocktail

Fibrosis in PCLS: comparing TGF-β and fibrotic cocktail

Abstract Introduction Fibrotic cocktail (FC) is a combination of pro-fibrotic and pro-inflammatory mediators that induces early fibrotic changes in organotypic lung models. We hypothesised that transforming growth factor beta 1 (TGF-β1) alone induces a pro-fibrotic effect similar to FC. Our aim was...

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Bibliographic Details
Main Authors: Carlos Machahua, Thomas M. Marti, Patrick Dorn, Manuela Funke-Chambour
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Respiratory Research
Subjects:
Precision cut lung slices
Fibrotic cocktail
Transforming growth factor beta 1
Ex vivo model
Fibrotic markers
Lung fibrosis
Online Access:https://doi.org/10.1186/s12931-025-03110-2
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