Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling

Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling

This study investigates the role of Rho GTPases, specifically Cdc42, Rac1, and RhoA, in platelet-derived growth factor receptors (PDGFRα and PDGFRβ) signaling. Signal transducer and activator of transcription (STAT) proteins, essential for cellular processes such as proliferation and immune response...

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Bibliographic Details
Main Authors: Erik Wåhlén, Johan Lennartsson, Johan Heldin
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Biochemistry and Biophysics Reports
Subjects:
PDGFR
Cdc42
Rac1
RhoA
Rho GTPases
STAT
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580824001924
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