Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling
This study investigates the role of Rho GTPases, specifically Cdc42, Rac1, and RhoA, in platelet-derived growth factor receptors (PDGFRα and PDGFRβ) signaling. Signal transducer and activator of transcription (STAT) proteins, essential for cellular processes such as proliferation and immune response...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | Biochemistry and Biophysics Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405580824001924 |
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| author | Erik Wåhlén Johan Lennartsson Johan Heldin |
| author_facet | Erik Wåhlén Johan Lennartsson Johan Heldin |
| author_sort | Erik Wåhlén |
| collection | DOAJ |
| description | This study investigates the role of Rho GTPases, specifically Cdc42, Rac1, and RhoA, in platelet-derived growth factor receptors (PDGFRα and PDGFRβ) signaling. Signal transducer and activator of transcription (STAT) proteins, essential for cellular processes such as proliferation and immune response, are activated downstream of PDGFRs. Dysregulation of these pathways is linked to various diseases, including cancer. The current study examines the effects of Rho GTPase depletion on PDGFR phosphorylation, STAT protein stability, and downstream signaling. Results indicate that depletion of Cdc42, Rac1, or RhoA impairs PDGFR phosphorylation and reduces STAT1 and STAT3 signaling, without significantly affecting AKT and ERK1/2 pathways. The findings highlight the critical regulatory roles of Rho GTPases in PDGFR-mediated STAT signaling. |
| format | Article |
| id | doaj-art-0ead78c0dd9f4c8dab4a3183a22ef1f2 |
| institution | Kabale University |
| issn | 2405-5808 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biochemistry and Biophysics Reports |
| spelling | doaj-art-0ead78c0dd9f4c8dab4a3183a22ef1f22024-12-04T05:13:00ZengElsevierBiochemistry and Biophysics Reports2405-58082024-12-0140101828Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signalingErik Wåhlén0Johan Lennartsson1Johan Heldin2Department of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, SE-75124, Uppsala, SwedenDepartment of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, SE-75124, Uppsala, SwedenCorresponding author.; Department of Pharmaceutical Biosciences, Uppsala University, Husargatan 3, SE-75124, Uppsala, SwedenThis study investigates the role of Rho GTPases, specifically Cdc42, Rac1, and RhoA, in platelet-derived growth factor receptors (PDGFRα and PDGFRβ) signaling. Signal transducer and activator of transcription (STAT) proteins, essential for cellular processes such as proliferation and immune response, are activated downstream of PDGFRs. Dysregulation of these pathways is linked to various diseases, including cancer. The current study examines the effects of Rho GTPase depletion on PDGFR phosphorylation, STAT protein stability, and downstream signaling. Results indicate that depletion of Cdc42, Rac1, or RhoA impairs PDGFR phosphorylation and reduces STAT1 and STAT3 signaling, without significantly affecting AKT and ERK1/2 pathways. The findings highlight the critical regulatory roles of Rho GTPases in PDGFR-mediated STAT signaling.http://www.sciencedirect.com/science/article/pii/S2405580824001924PDGFRCdc42Rac1RhoARho GTPasesSTAT |
| spellingShingle | Erik Wåhlén Johan Lennartsson Johan Heldin Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling Biochemistry and Biophysics Reports PDGFR Cdc42 Rac1 RhoA Rho GTPases STAT |
| title | Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling |
| title_full | Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling |
| title_fullStr | Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling |
| title_full_unstemmed | Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling |
| title_short | Depletion of the Rho GTPases Cdc42, Rac1 or RhoA reduces PDGF-induced STAT1 and STAT3 signaling |
| title_sort | depletion of the rho gtpases cdc42 rac1 or rhoa reduces pdgf induced stat1 and stat3 signaling |
| topic | PDGFR Cdc42 Rac1 RhoA Rho GTPases STAT |
| url | http://www.sciencedirect.com/science/article/pii/S2405580824001924 |
| work_keys_str_mv | AT erikwahlen depletionoftherhogtpasescdc42rac1orrhoareducespdgfinducedstat1andstat3signaling AT johanlennartsson depletionoftherhogtpasescdc42rac1orrhoareducespdgfinducedstat1andstat3signaling AT johanheldin depletionoftherhogtpasescdc42rac1orrhoareducespdgfinducedstat1andstat3signaling |