β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury

β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury

Abstract Neutrophils are the first responders among peripheral immune cells to infiltrate the central nervous system following a traumatic brain injury (TBI), triggering neuroinflammation that can exacerbate secondary tissue damage. The precise molecular controls that dictate the inflammatory behavi...

Full description

Saved in:

Bibliographic Details
Main Authors:	Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang
Format:	Article
Language:	English
Published:	BMC 2025-02-01
Series:	Cell Communication and Signaling
Subjects:	Traumatic brain injury Neuroinflammation β2 integrin Neutrophil extracellular traps Intercellular adhesion molecule-1
Online Access:	https://doi.org/10.1186/s12964-025-02071-9
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Nanoscopy reveals integrin clustering reliant on kindlin-3 but not talin-1
by: Yuanyuan Wu, et al.
Published: (2025-01-01)

Extracellular vesicle surface engineering with integrins (ITGAL & ITGB2) to specifically target ICAM-1-expressing endothelial cells
by: Markus Bergqvist, et al.
Published: (2025-01-01)

Keratinocyte Integrin α3β1 Promotes Efficient Healing of Wound Epidermis
by: Sanjana Dhulipalla, et al.
Published: (2025-01-01)

Effect of integrin α5 on NLRP3 expression in periodontal ligament fibroblasts within an inflammatory microenvironment
by: DAI Jingyi, CAI Hongxuan, SI Weixing, ZHANG Zan, WANG Zhurui, LI Mengsen, TIAN Ya guang
Published: (2025-01-01)

Effect of Qing'e Formula on OPN, BSP and Integrin ɑ<sub>v</sub>β<sub>3</sub>Expression in Bone Tissue of Ovariectomized Rats
by: Yuqing SUN, et al.
Published: (2017-06-01)

Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits
by: Yuxin Hao, et al.
Published: (2024-12-01)

High matrix stiffness accelerates migration of hepatocellular carcinoma cells through the integrin β1-Plectin-F-actin axis
by: Zhihui Wang, et al.
Published: (2025-01-01)

Injectable double network hydrogel with adjustable stiffness for modulation of macrophage polarization
by: Jinxin Wu, et al.
Published: (2025-02-01)

Aberrant Development of Thymocytesin Mice Lacking Laminin-2
by: William J. Magner, et al.
Published: (2000-01-01)

Endocytic recycling is central to circadian collagen fibrillogenesis and disrupted in fibrosis
by: Joan Chang, et al.
Published: (2025-01-01)

Effects of different types of ginseng on intercellular wireless communication networks and central carbon metabolism pathways
by: Yujiao Liu, et al.
Published: (2025-11-01)

The alphavirus determinants of intercellular long extension formation
by: Caroline K. Martin, et al.
Published: (2025-02-01)

Pathogenic and therapeutic roles of extracellular vesicles in sepsis
by: Benshuai You, et al.
Published: (2025-02-01)

Regeneration of Rabbit Auricular Cartilage After the Intravenous Stem Cell Injection
by: Pavlo Virych, et al.
Published: (2023-11-01)

Prominosomes - a particular class of extracellular vesicles containing prominin-1/CD133?
by: Jana Karbanová, et al.
Published: (2025-01-01)

Transcriptomic signatures of cold acclimated adipocytes reveal CXCL12 as a Brown autocrine and paracrine chemokine
by: Marina Agueda-Oyarzabal, et al.
Published: (2025-03-01)

Bioinformatics analysis combined with experimental validation reveals the biological role of the ILK gene in prostate cancer
by: Xiao-xiang Yu, et al.
Published: (2025-01-01)

Role of Extracellular Matrix-Mediated Interactionsin Thymocyte Migration
by: Wilson Savino, et al.
Published: (2000-01-01)

Mechanistic insights into epithelial-mesenchymal transition mediated cisplatin resistance in ovarian cancer
by: Taha Umair Wani, et al.
Published: (2025-01-01)

Visualization of microbial biofilms in case of digestive disorders in lambs
by: E. M. Lenchenko, et al.
Published: (2021-03-01)

Gap-Junction Communication Pathways in Germinal Center Reactions
by: Tibor Krenacs, et al.
Published: (1998-01-01)

Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease
by: Jiangyuan Jin, et al.
Published: (2024-12-01)

Dental pulp stem cell-derived intracellular vesicles prevent orthodontic relapse by inhibiting PI3K/Akt/NF-κB-mediated osteoclast activity
by: Boyuan Peng, et al.
Published: (2025-01-01)

T Cell Migration in Three-dimensional ExtracellularMatrix: Guidance by Polarity and Sensations
by: Peter Friedl, et al.
Published: (2000-01-01)

Rap1 Guanosine Triphosphate Hydrolase (GTPase) Regulates Shear Stress-Mediated Adhesion of Mesenchymal Stromal Cells
by: Melanie Giesen, et al.
Published: (2025-01-01)

Balancing Thymocyte Adhesion and Motility:A Functional Linkage Between β1 Lntegrinsand The Motility Receptor RHAMM
by: Sheryl L. Gares, et al.
Published: (2000-01-01)

The influence of probiotic administration on selected leukocyte subpopulations and the serum amyloid A concentration in the peripheral blood of dairy cows during different lactation periods
by: Brodzki Piotr, et al.
Published: (2024-10-01)

Single-cell and spatial transcriptomics in endocrine research
by: Ryusaku Matsumoto, et al.
Published: (2024-02-01)

Bundle sheath cell-dependent chloroplast movement in mesophyll cells of C4 plants analyzed using live leaf-section imaging
by: Yuta Kato, et al.
Published: (2025-02-01)

Continuously relapsing (for two years) course of diarrheal variant of IBS (<i>Clinical case</i>)
by: Ye. A. Poluektova, et al.
Published: (2013-10-01)

Studying breast cancer lung metastasis using a multi-compartment microfluidic device with a mimetic tumor-stroma interaction model
by: Bahareh Zarin, et al.
Published: (2025-03-01)

Novel genes involved in vascular dysfunction of the middle temporal gyrus in Alzheimer’s disease: transcriptomics combined with machine learning analysis
by: Meiling Wang, et al.
Published: (2025-12-01)

Large soluble CD18 complexes with exclusive ICAM-1-binding properties are shed during immune cell migration in inflammation
by: Alexey Ferapontov, et al.
Published: (2025-06-01)

Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury
by: Guihong Shi, et al.
Published: (2025-04-01)

Triiodothyronine (T3) increases the expression of the amphiregulin (AREG) oncogene by activating extranuclear pathways in MCF-7 breast cancer cells
by: Maria Teresa De Sibio, et al.
Published: (2025-01-01)

Reversible Ca2+ signaling and enhanced paracellular transport in endothelial monolayer induced by acoustic bubbles and targeted microbeads
by: Jiawei Lin, et al.
Published: (2025-01-01)

LIPUS promotes osteogenic differentiation of rat BMSCs and osseointegration of dental implants by regulating ITGA11 and focal adhesion pathway
by: Chao Liang, et al.
Published: (2025-01-01)

Long-Term Therapeutic Effects of <sup>225</sup>Ac-DOTA-E[c(RGDfK)]<sub>2</sub> Induced by Radiosensitization via G2/M Arrest in Pancreatic Ductal Adenocarcinoma
by: Mitsuyoshi Yoshimoto, et al.
Published: (2024-12-01)

Dynamic development of microglia and macrophages after spinal cord injury
by: Hu-Yao Zhou, et al.
Published: (2025-12-01)

Effects of colchicine adjuvant therapy on disease control, serum NALP3, sICAM-1, MMP-9 and MMP-13 in patients with coronary heart disease and acute gout attack
by: Bingxun Wang, et al.
Published: (2025-01-01)