Airway MMP-12 and DNA methylation in COPD: an integrative approach

Airway MMP-12 and DNA methylation in COPD: an integrative approach

Abstract Background In COPD, the balance between matrix metalloproteinases (MMPs) and their natural inhibitors [tissue inhibitors of metalloproteinases (TIMPs)] is shifted towards excessive degradation, reflected in bronchoalveolar lavage (BAL) as increased MMP concentrations. Because of their criti...

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Bibliographic Details
Main Authors: Jonas Eriksson Ström, Simon Kebede Merid, Robert Linder, Jamshid Pourazar, Anne Lindberg, Erik Melén, Annelie F. Behndig
Format: Article
Language:English
Published: BMC 2025-01-01
Series:Respiratory Research
Subjects:
Chronic obstructive pulmonary disease (COPD)
DNA methylation
Matrix metalloproteinases (MMPs)
Extracellular matrix remodelling
Multiomics
Bronchoscopy
Online Access:https://doi.org/10.1186/s12931-024-03088-3
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