Causal Associations of Epigenetic Age Acceleration With Stroke and Its Functional Outcome: A Two‐Sample, Two‐Step Mendelian Randomization Study

Causal Associations of Epigenetic Age Acceleration With Stroke and Its Functional Outcome: A Two‐Sample, Two‐Step Mendelian Randomization Study

ABSTRACT Background Emerging evidence from observational studies suggested that epigenetic age acceleration may result in an increased incidence of stroke and poorer functional outcomes after a stroke. However, the causality of these associations remains controversial and may be confounded by bias....

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Main Authors: Baizhi Qiu, Shuyang Wen, Zifan Li, Yuxin Cai, Qi Zhang, Yuting Zeng, Shuqi Zheng, Zhishan Lin, Yupeng Xiao, Jihua Zou, Guozhi Huang, Qing Zeng
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Brain and Behavior
Subjects:
epigenetic age
mediation
Mendelian randomization
stroke
Online Access:https://doi.org/10.1002/brb3.70412
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