Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities
In recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which may serve as important targets for molecular...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-12-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1484027/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846128011318919168 |
|---|---|
| author | Hongliang Liu Xi Wang Lingyan Liu Bingsong Yan Fabo Qiu Bin Zhou |
| author_facet | Hongliang Liu Xi Wang Lingyan Liu Bingsong Yan Fabo Qiu Bin Zhou |
| author_sort | Hongliang Liu |
| collection | DOAJ |
| description | In recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which may serve as important targets for molecular therapy. In the present review, we focus on the molecular characteristics, molecular diagnostics, driver genes, and molecular mechanisms of liposarcoma. We also discuss the clinical research progress of related targeted therapies, with an aim to provide a reference and crucial insights for colleagues in the field. |
| format | Article |
| id | doaj-art-0e303b75b8ce4ab2b853e94e3ab3392e |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-0e303b75b8ce4ab2b853e94e3ab3392e2024-12-11T06:45:03ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-12-011410.3389/fonc.2024.14840271484027Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunitiesHongliang Liu0Xi Wang1Lingyan Liu2Bingsong Yan3Fabo Qiu4Bin Zhou5Department of Hepatobiliary and Pancreatic Surgery & Retroperitoneal Tumor Surgery, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Oncology, Women and Children’s Hospital Affiliated to Qingdao University, Qingdao, ChinaDepartment of Gastroenterology, Qilu Hospital of Shandong University, Jinan, ChinaDepartment of Hepatobiliary Surgery, Women and Children’s Hospital Affiliated to Qingdao University, Qingdao, ChinaDepartment of Hepatobiliary and Pancreatic Surgery & Retroperitoneal Tumor Surgery, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Hepatobiliary and Pancreatic Surgery & Retroperitoneal Tumor Surgery, The Affiliated Hospital of Qingdao University, Qingdao, ChinaIn recent years, an increasing number of studies have utilized molecular biology techniques to reveal important molecular heterogeneity among different subtypes of liposarcoma. Each subtype exhibits distinct genetic patterns and molecular pathways, which may serve as important targets for molecular therapy. In the present review, we focus on the molecular characteristics, molecular diagnostics, driver genes, and molecular mechanisms of liposarcoma. We also discuss the clinical research progress of related targeted therapies, with an aim to provide a reference and crucial insights for colleagues in the field.https://www.frontiersin.org/articles/10.3389/fonc.2024.1484027/fullliposarcomadriver genesmolecular pathogenesistargeted therapyoutlook |
| spellingShingle | Hongliang Liu Xi Wang Lingyan Liu Bingsong Yan Fabo Qiu Bin Zhou Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities Frontiers in Oncology liposarcoma driver genes molecular pathogenesis targeted therapy outlook |
| title | Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities |
| title_full | Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities |
| title_fullStr | Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities |
| title_full_unstemmed | Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities |
| title_short | Targeting liposarcoma: unveiling molecular pathways and therapeutic opportunities |
| title_sort | targeting liposarcoma unveiling molecular pathways and therapeutic opportunities |
| topic | liposarcoma driver genes molecular pathogenesis targeted therapy outlook |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1484027/full |
| work_keys_str_mv | AT hongliangliu targetingliposarcomaunveilingmolecularpathwaysandtherapeuticopportunities AT xiwang targetingliposarcomaunveilingmolecularpathwaysandtherapeuticopportunities AT lingyanliu targetingliposarcomaunveilingmolecularpathwaysandtherapeuticopportunities AT bingsongyan targetingliposarcomaunveilingmolecularpathwaysandtherapeuticopportunities AT faboqiu targetingliposarcomaunveilingmolecularpathwaysandtherapeuticopportunities AT binzhou targetingliposarcomaunveilingmolecularpathwaysandtherapeuticopportunities |