Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults
Background: Hyperhomocysteinemia (HHcy) is proposed as a risk factor for coronary artery disease (CAD), while dyslipidemia is a well-established risk factor. HHcy can arise from deficiencies in Vitamin B12 (Vit B), Vitamin B6, and folic acid (FA), as well as from kidney diseases or genetic factors....
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Biomedical and Biotechnology Research Journal |
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| Online Access: | https://journals.lww.com/10.4103/bbrj.bbrj_304_24 |
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| _version_ | 1841554754879094784 |
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| author | K. Sowndarya Anupama Hegde Neelam M. Pawar Ramya Shenoy |
| author_facet | K. Sowndarya Anupama Hegde Neelam M. Pawar Ramya Shenoy |
| author_sort | K. Sowndarya |
| collection | DOAJ |
| description | Background:
Hyperhomocysteinemia (HHcy) is proposed as a risk factor for coronary artery disease (CAD), while dyslipidemia is a well-established risk factor. HHcy can arise from deficiencies in Vitamin B12 (Vit B), Vitamin B6, and folic acid (FA), as well as from kidney diseases or genetic factors. This study aims to evaluate homocysteine (Hcy) levels as potential predictors of CAD risk in apparently healthy adults.
Methods:
A cross-sectional analytical study was conducted with 62 healthy individuals aged 20–62 years visiting a tertiary healthcare center for routine health checks. After obtaining ethical clearance and informed consent, serum Hcy levels, fasting lipid profiles (total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein), Vit B12, and FA levels were measured using standard laboratory techniques. Statistical analyses were conducted using SPSS version 20.
Results:
HHcy was detected in 43.54% of participants, with 59% of those exhibiting either isolated or combined vitamin deficiencies. A significant negative correlation was found between Hcy levels and both Vit B12 and FA (P < 0.001). Notably, there was no significant correlation between Hcy levels and traditional lipid profile markers.
Conclusion:
The findings indicate that apparently healthy adults can have elevated Hcy levels significantly associated with Vit B12 and FA status, but not with conventional CAD risk markers such as lipid profiles. These results suggest the need for further investigation into Hcy as a viable alternative marker for CAD risk in young adults, emphasizing the importance of monitoring vitamin levels to mitigate cardiovascular risks. |
| format | Article |
| id | doaj-art-0e243a45f2f546e6bb1020cdb48e514a |
| institution | Kabale University |
| issn | 2588-9834 2588-9842 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Biomedical and Biotechnology Research Journal |
| spelling | doaj-art-0e243a45f2f546e6bb1020cdb48e514a2025-01-08T09:51:27ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342588-98422024-12-018448749210.4103/bbrj.bbrj_304_24Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy AdultsK. SowndaryaAnupama HegdeNeelam M. PawarRamya ShenoyBackground: Hyperhomocysteinemia (HHcy) is proposed as a risk factor for coronary artery disease (CAD), while dyslipidemia is a well-established risk factor. HHcy can arise from deficiencies in Vitamin B12 (Vit B), Vitamin B6, and folic acid (FA), as well as from kidney diseases or genetic factors. This study aims to evaluate homocysteine (Hcy) levels as potential predictors of CAD risk in apparently healthy adults. Methods: A cross-sectional analytical study was conducted with 62 healthy individuals aged 20–62 years visiting a tertiary healthcare center for routine health checks. After obtaining ethical clearance and informed consent, serum Hcy levels, fasting lipid profiles (total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein), Vit B12, and FA levels were measured using standard laboratory techniques. Statistical analyses were conducted using SPSS version 20. Results: HHcy was detected in 43.54% of participants, with 59% of those exhibiting either isolated or combined vitamin deficiencies. A significant negative correlation was found between Hcy levels and both Vit B12 and FA (P < 0.001). Notably, there was no significant correlation between Hcy levels and traditional lipid profile markers. Conclusion: The findings indicate that apparently healthy adults can have elevated Hcy levels significantly associated with Vit B12 and FA status, but not with conventional CAD risk markers such as lipid profiles. These results suggest the need for further investigation into Hcy as a viable alternative marker for CAD risk in young adults, emphasizing the importance of monitoring vitamin levels to mitigate cardiovascular risks.https://journals.lww.com/10.4103/bbrj.bbrj_304_24coronary artery diseasefolic acidhomocysteinelipid profilevitamin b12 |
| spellingShingle | K. Sowndarya Anupama Hegde Neelam M. Pawar Ramya Shenoy Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults Biomedical and Biotechnology Research Journal coronary artery disease folic acid homocysteine lipid profile vitamin b12 |
| title | Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults |
| title_full | Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults |
| title_fullStr | Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults |
| title_full_unstemmed | Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults |
| title_short | Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults |
| title_sort | elevated homocysteine levels and vitamin deficiencies as potential risk markers for coronary artery disease in apparently healthy adults |
| topic | coronary artery disease folic acid homocysteine lipid profile vitamin b12 |
| url | https://journals.lww.com/10.4103/bbrj.bbrj_304_24 |
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