Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory Modeling
ObjectiveBased on Hammersmith Function Motor Scale Expanded （HFMSE），the study aimed at constructing item response model （IRM） to evaluate the functioning of patients with spinal muscular atrophy （SMA） and exploring the metrical characteristics of HFMSE.MethodsWe recruited 23 SMA patients who receive...
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Editorial Office of Rehabilitation Medicine
2024-01-01
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| Series: | 康复学报 |
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| author | FAN Yabei CHEN Jinjin GE Panli CHENG Xi ZHANG Yichen LIN Feng |
| author_facet | FAN Yabei CHEN Jinjin GE Panli CHENG Xi ZHANG Yichen LIN Feng |
| author_sort | FAN Yabei |
| collection | DOAJ |
| description | ObjectiveBased on Hammersmith Function Motor Scale Expanded （HFMSE），the study aimed at constructing item response model （IRM） to evaluate the functioning of patients with spinal muscular atrophy （SMA） and exploring the metrical characteristics of HFMSE.MethodsWe recruited 23 SMA patients who received corrective treatment in the Department of Geriatric Neurology and the Department of Pediatrics of the First Affiliated Hospital with Nanjing Medical University from February 2021 to June 2023. IRM was constructed using these repeated measurement data based on stack design<sup>［1］</sup>. ，The comparisons between well-fitted models were based on likelihood ratio. And item guessing，carelessness，difficultyand personal abilities （θ） of selected optimal model were calculated. Differential test functioning （DTF） test was conducted for gender and rehabilitation therapy to test the bias. Monte Carlo simulation was used to prove that the item difficulty distribution of the model was not affected by the sampling process. And person-item plot was drawn according to the median expected difficulty. and the differences in the difficulty of each item in HFMSE scale and personal abilities among each evaluations were discussed.ResultsA total of 32items were included in this study and 4 alternative models were constructed. Three-parametric logistic model was selected as the optimal model with the best fitness （<italic>p</italic> > 0. 05，M<sub>2</sub> statistics = 479. 75）. In 3PLM，the caution of all items was 1，and the discrimination，guessing and difficulty of the items were calculated. There were no DTFs for gender and rehabilitation therapy. The results showed high reliability （Cronbach's α = 0. 955，LCRC = 0. 981） and validity ［θ value is positively correlated with the original total score （P<0. 001，r = 0. 99）］ of 3PLM. There was conversion between personal abilities θ value and the total score of the scale：θ=-1. 63 + 0. 0651TTS－1. 39×10<sup>-5</sup>TTS<sup>2</sup>. A person-item plot showing the location of item parameters and individual parameters on the personal abilities （θ） scale was used to observe the relationship between θ values and item difficulties.ConclusionThe IRT model based on HFMSE offered a new approach to evaluate functional levels of SMA patients and difficulties of items. The calculation of item guessing，carelessness and difficulty of selected optimal model provides recommendations for better clinical practice of HFMSE. The study offers a new perspective for the assessment of the functions of SMA patients and guidance for the development of rehabilitation programs. |
| format | Article |
| id | doaj-art-0e2301adcda4459191d8d4ed8f9846e9 |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
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| series | 康复学报 |
| spelling | doaj-art-0e2301adcda4459191d8d4ed8f9846e92025-01-14T10:09:10ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282024-01-011876587297Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory ModelingFAN YabeiCHEN JinjinGE PanliCHENG XiZHANG YichenLIN FengObjectiveBased on Hammersmith Function Motor Scale Expanded （HFMSE），the study aimed at constructing item response model （IRM） to evaluate the functioning of patients with spinal muscular atrophy （SMA） and exploring the metrical characteristics of HFMSE.MethodsWe recruited 23 SMA patients who received corrective treatment in the Department of Geriatric Neurology and the Department of Pediatrics of the First Affiliated Hospital with Nanjing Medical University from February 2021 to June 2023. IRM was constructed using these repeated measurement data based on stack design<sup>［1］</sup>. ，The comparisons between well-fitted models were based on likelihood ratio. And item guessing，carelessness，difficultyand personal abilities （θ） of selected optimal model were calculated. Differential test functioning （DTF） test was conducted for gender and rehabilitation therapy to test the bias. Monte Carlo simulation was used to prove that the item difficulty distribution of the model was not affected by the sampling process. And person-item plot was drawn according to the median expected difficulty. and the differences in the difficulty of each item in HFMSE scale and personal abilities among each evaluations were discussed.ResultsA total of 32items were included in this study and 4 alternative models were constructed. Three-parametric logistic model was selected as the optimal model with the best fitness （<italic>p</italic> > 0. 05，M<sub>2</sub> statistics = 479. 75）. In 3PLM，the caution of all items was 1，and the discrimination，guessing and difficulty of the items were calculated. There were no DTFs for gender and rehabilitation therapy. The results showed high reliability （Cronbach's α = 0. 955，LCRC = 0. 981） and validity ［θ value is positively correlated with the original total score （P<0. 001，r = 0. 99）］ of 3PLM. There was conversion between personal abilities θ value and the total score of the scale：θ=-1. 63 + 0. 0651TTS－1. 39×10<sup>-5</sup>TTS<sup>2</sup>. A person-item plot showing the location of item parameters and individual parameters on the personal abilities （θ） scale was used to observe the relationship between θ values and item difficulties.ConclusionThe IRT model based on HFMSE offered a new approach to evaluate functional levels of SMA patients and difficulties of items. The calculation of item guessing，carelessness and difficulty of selected optimal model provides recommendations for better clinical practice of HFMSE. The study offers a new perspective for the assessment of the functions of SMA patients and guidance for the development of rehabilitation programs.http://kfxb.publish.founderss.cn/thesisDetails?columnId=76587297&Fpath=home&index=0spinal muscular atrophy (SMA)hammersmith functional motor scale expanded (HFMSE)item response theoryfunctional analysis |
| spellingShingle | FAN Yabei CHEN Jinjin GE Panli CHENG Xi ZHANG Yichen LIN Feng Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory Modeling 康复学报 spinal muscular atrophy (SMA) hammersmith functional motor scale expanded (HFMSE) item response theory functional analysis |
| title | Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory Modeling |
| title_full | Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory Modeling |
| title_fullStr | Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory Modeling |
| title_full_unstemmed | Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory Modeling |
| title_short | Functional Analysis of Patients with Spinal Muscular Atrophy Based on Exploratory Item Response Theory Modeling |
| title_sort | functional analysis of patients with spinal muscular atrophy based on exploratory item response theory modeling |
| topic | spinal muscular atrophy (SMA) hammersmith functional motor scale expanded (HFMSE) item response theory functional analysis |
| url | http://kfxb.publish.founderss.cn/thesisDetails?columnId=76587297&Fpath=home&index=0 |
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