Efficacy and safety of neoadjuvant PD-1 inhibitors or PD-L1 inhibitors combined with chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis

Efficacy and safety of neoadjuvant PD-1 inhibitors or PD-L1 inhibitors combined with chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis

BackgroundThe objective of this meta-analysis was to assess the effectiveness and safety of neoadjuvant PD-1/L1 inhibitors plus chemoradiotherapy(CRT) for locally advanced rectal cancer (LARC).Materials and MethodsDatabases including PubMed, Embase, Cochrane Library and Web of Science were examined...

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Bibliographic Details
Main Authors: Jiaojiao Yu, Zhijing Wang, Mingxu Li, Hua Zhu, Xiaoxia Tang, Ke Luan, Yinhuan Zhi, Shan Yin, Yuanqi Su, Jingyan Long, Qubo He, Jieru Quan, Chenchen Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Pharmacology
Subjects:
PD-1 inhibitor
programmed cell death protein 1 inhibitor
programmed death-ligand 1 inhibitor
rectal cancer
neoadjuvant
chemoradiotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1570467/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1570467/full

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