Exploring Serum Ceruloplasmin Dynamics in Stage II Periodontitis: Pre- and PostPhase I Therapy Assessment
Objective: This study aimed to evaluate the concentration of ceruloplasmin (CP) in serum before and after Phase I periodontal therapy in patients with Stage II periodontitis. Materials and Methods: Forty subjects were divided into periodontally healthy subjects (n = 20) and Stage II periodontitis pa...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
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| Series: | Journal of International Clinical Dental Research Organization |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/jicdro.jicdro_44_24 |
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| Summary: | Objective:
This study aimed to evaluate the concentration of ceruloplasmin (CP) in serum before and after Phase I periodontal therapy in patients with Stage II periodontitis.
Materials and Methods:
Forty subjects were divided into periodontally healthy subjects (n = 20) and Stage II periodontitis patients (n = 20). Serum CP levels were assessed and compared with clinical parameters (plaque index, gingival bleeding index, probing pocket depth, and clinical attachment level) before and after Phase-I therapy. Serum CP was measured using the immunoturbidometric method. Statistical analysis was conducted using SPSS version 20.0, with significance set at P ≤ 0.05. The independent t-test compared periodontally healthy and Stage II periodontitis patients.
Results:
Significant reductions were noted in all clinical parameters and serum CP levels. The baseline mean serum CP was 26.03 ± 4.371, decreasing to 22.85 ± 3.971 after 3 months of Phase I therapy. The mean difference in serum CP from baseline to 3 months was 3.185 ± 1.16 (P = 0.000).
Conclusion:
Periodontal inflammation may elevate serum CP levels and clinical parameter values in Stage II periodontitis patients. Phase I therapy effectively decreased serum CP levels and improved clinical parameters, suggesting its potential in managing periodontal disease. |
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| ISSN: | 2231-0754 2231-5357 |