Bromodomain-containing protein 4 contributes to chronic postsurgical pain via activating TLR4/NF-kappaB-dependent neuroinflammation

Bromodomain-containing protein 4 contributes to chronic postsurgical pain via activating TLR4/NF-kappaB-dependent neuroinflammation

Abstract Background Chronic pain affects 1.5 billion individuals worldwide but remains woefully undertreated, particularly occurring in the populations undergoing surgical procedures. Increasing evidence indicates that epigenetic modifications are involved in the pathogenesis of chronic pain. This s...

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Bibliographic Details
Main Authors: Ruichen Shu, Yuan Li, Zengli Zhang, Xuan Zhang, Shan Guan, Kaiyuan Wang, Yiqing Yin
Format: Article
Language:English
Published: BMC 2025-07-01
Series:BMC Anesthesiology
Subjects:
Chronic postsurgical pain
Brd4
Epigenetics
Neuroinflammation
NF-κB
Online Access:https://doi.org/10.1186/s12871-025-03216-6
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