Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

Mechanical forces pattern endocardial Notch activation via mTORC2-PKC pathway

Notch signaling has been identified as a key regulatory pathway in patterning the endocardium through activation of endothelial-to-mesenchymal transition (EMT) in the atrioventricular canal (AVC) and proximal outflow tract (OFT) region. However, the precise mechanism underlying Notch activation rema...

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Bibliographic Details
Main Authors: Yunfei Mu, Shijia Hu, Xiangyang Liu, Xin Tang, Jiayi Lin, Hongjun Shi
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-02-01
Series:eLife
Subjects:
cardiac patterning
endocardium
EMT
notch
shear stress
mechanosensing
Online Access:https://elifesciences.org/articles/97268
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