Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives
Abstract Exosomes, nano-sized extracellular vesicles, facilitate intercellular communication by transferring biomolecules such as microRNAs (miRNAs), which are key regulators of gene expression. While mammalian-derived exosomes (MDEs) have shown therapeutic promise, their clinical application has be...
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BMC
2025-08-01
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| Series: | Journal of Nanobiotechnology |
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| Online Access: | https://doi.org/10.1186/s12951-025-03602-9 |
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| author | Kingsley Miyanda Tembo Xiaohui Wang Mansoor Bolideei Qianrui Liu Farouk Baboni Mohammad Javad Mehran Fei Sun Cong-Yi Wang |
| author_facet | Kingsley Miyanda Tembo Xiaohui Wang Mansoor Bolideei Qianrui Liu Farouk Baboni Mohammad Javad Mehran Fei Sun Cong-Yi Wang |
| author_sort | Kingsley Miyanda Tembo |
| collection | DOAJ |
| description | Abstract Exosomes, nano-sized extracellular vesicles, facilitate intercellular communication by transferring biomolecules such as microRNAs (miRNAs), which are key regulators of gene expression. While mammalian-derived exosomes (MDEs) have shown therapeutic promise, their clinical application has been limited by challenges such as immune-related toxicities, low yield and high production costs. In contrast, plant-derived exosome-like nanoparticles (PELNs) offer a sustainable, biocompatible, and cost-effective alternative, encapsulating a diverse array of bioactive miRNAs with significant therapeutic potential. Studies have demonstrated the ability of PELN-derived miRNAs in cross-kingdom communication, effectively transferring into mammalian cells, where they modulate disease-related pathways, including cancer, inflammation, metabolism, and neurodegeneration. This review explores the bioactivity of plant-derived miRNAs, highlighting their role as novel therapeutic agents. The study explores the bioactivity and potential mechanisms by which these miRNAs influence human cellular processes, focusing on their ability to regulate gene expression in different tissues. Additionally, the study examines recent advances in PELN research, emphasizing their potential for clinical translation in precision medicine, and highlights challenges and future prospects in harnessing the therapeutic capabilities of these bioactive miRNAs. This review underscores the potential of PELNs to revolutionize therapeutic strategies, offering a sustainable, biocompatible, and cost-effective platform for targeted miRNA delivery, paving the way for innovative interventions leveraging nature’s own nanocarriers. Graphical Abstract |
| format | Article |
| id | doaj-art-0dd01e42b4d542e7a5d8fe9f09891dce |
| institution | Kabale University |
| issn | 1477-3155 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | BMC |
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| series | Journal of Nanobiotechnology |
| spelling | doaj-art-0dd01e42b4d542e7a5d8fe9f09891dce2025-08-20T03:46:27ZengBMCJournal of Nanobiotechnology1477-31552025-08-0123114410.1186/s12951-025-03602-9Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectivesKingsley Miyanda Tembo0Xiaohui Wang1Mansoor Bolideei2Qianrui Liu3Farouk Baboni4Mohammad Javad Mehran5Fei Sun6Cong-Yi Wang7The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and TechnologyThe Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and TechnologyThe Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and TechnologyThe Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and TechnologyInstitute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Department of Biotechnology, JSS Research Foundation, SJCE Technical Campus, University of MysoreThe Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and TechnologyTongji Shanxi Hospital, Shanxi Bethune Hospital, Third Hospital of Shanxi Medical University, the Key Laboratory of Endocrine and Metabolic Diseases of Shanxi Province, Shanxi Medical UniversityAbstract Exosomes, nano-sized extracellular vesicles, facilitate intercellular communication by transferring biomolecules such as microRNAs (miRNAs), which are key regulators of gene expression. While mammalian-derived exosomes (MDEs) have shown therapeutic promise, their clinical application has been limited by challenges such as immune-related toxicities, low yield and high production costs. In contrast, plant-derived exosome-like nanoparticles (PELNs) offer a sustainable, biocompatible, and cost-effective alternative, encapsulating a diverse array of bioactive miRNAs with significant therapeutic potential. Studies have demonstrated the ability of PELN-derived miRNAs in cross-kingdom communication, effectively transferring into mammalian cells, where they modulate disease-related pathways, including cancer, inflammation, metabolism, and neurodegeneration. This review explores the bioactivity of plant-derived miRNAs, highlighting their role as novel therapeutic agents. The study explores the bioactivity and potential mechanisms by which these miRNAs influence human cellular processes, focusing on their ability to regulate gene expression in different tissues. Additionally, the study examines recent advances in PELN research, emphasizing their potential for clinical translation in precision medicine, and highlights challenges and future prospects in harnessing the therapeutic capabilities of these bioactive miRNAs. This review underscores the potential of PELNs to revolutionize therapeutic strategies, offering a sustainable, biocompatible, and cost-effective platform for targeted miRNA delivery, paving the way for innovative interventions leveraging nature’s own nanocarriers. Graphical Abstracthttps://doi.org/10.1186/s12951-025-03602-9MicroRNAs (miRNA)Plant-Derived Exosome-Like Nanoparticles (PELNs)Cross-Kingdom communicationBioactivityGene regulationTherapeutic potential |
| spellingShingle | Kingsley Miyanda Tembo Xiaohui Wang Mansoor Bolideei Qianrui Liu Farouk Baboni Mohammad Javad Mehran Fei Sun Cong-Yi Wang Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives Journal of Nanobiotechnology MicroRNAs (miRNA) Plant-Derived Exosome-Like Nanoparticles (PELNs) Cross-Kingdom communication Bioactivity Gene regulation Therapeutic potential |
| title | Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives |
| title_full | Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives |
| title_fullStr | Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives |
| title_full_unstemmed | Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives |
| title_short | Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives |
| title_sort | exploring the bioactivity of micrornas originated from plant derived exosome like nanoparticles pelns current perspectives |
| topic | MicroRNAs (miRNA) Plant-Derived Exosome-Like Nanoparticles (PELNs) Cross-Kingdom communication Bioactivity Gene regulation Therapeutic potential |
| url | https://doi.org/10.1186/s12951-025-03602-9 |
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