CXCR4 antagonism ameliorates leukocyte abnormalities in a preclinical model of WHIM syndrome

CXCR4 antagonism ameliorates leukocyte abnormalities in a preclinical model of WHIM syndrome

BackgroundWHIM (Warts, Hypogammaglobulinemia, Infections, and Myelokathexis) syndrome is an ultra-rare, combined primary immunodeficiency and chronic neutropenic disorder characterized by a range of clinical presentations, including peripheral neutropenia, lymphopenia, and recurrent infections. WHIM...

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Main Authors: Lilian Roland, Chi Huu Nguyen, Katarina Zmajkovicova, Mélanie Khamyath, Maria Kalogeraki, Bérénice Schell, Vanessa Gourhand, Vincent Rondeau, Zeina Abou Nader, Halenya Monticelli, Barbara Maierhofer, Robert Johnson, Arthur Taveras, Marion Espéli, Karl Balabanian
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
WHIM syndrome
primary immunodeficiency
chronic neutropenia
CXCR4 antagonism
preclinical study
neutrophil function
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1468823/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1468823/full

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