Tracking changes in autonomic function by coupled analysis of wavelet-based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile Ehlers–Danlos syndrome
IntroductionPeople with hypermobile Ehlers–Danlos syndrome (hEDS) experience multisystemic dysfunction with varying severity and unpredictability of flare occurrence. Cohort studies suggest that individuals with hEDS have a higher risk for autonomic dysfunction. The gold standard for assessing auton...
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Frontiers Media S.A.
2025-01-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2024.1499582/full |
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| author | Sarah A. Mathena Robert M. Allen Robert M. Allen Christina Laukaitis Christina Laukaitis Christina Laukaitis Jennifer G. Andrews |
| author_facet | Sarah A. Mathena Robert M. Allen Robert M. Allen Christina Laukaitis Christina Laukaitis Christina Laukaitis Jennifer G. Andrews |
| author_sort | Sarah A. Mathena |
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| description | IntroductionPeople with hypermobile Ehlers–Danlos syndrome (hEDS) experience multisystemic dysfunction with varying severity and unpredictability of flare occurrence. Cohort studies suggest that individuals with hEDS have a higher risk for autonomic dysfunction. The gold standard for assessing autonomic function, clinically, is the heart rate variability (HRV) assessment from 24-h Holter monitor electrocardiogram data, but this is expensive and can only be performed in short durations. Since their advent, biometric devices have been a non-invasive method for tracking HRV to assess autonomic function. This study aimed to understand the intra- and inter-individual variability in autonomic function and to associate this variability with gastrointestinal symptoms in individuals with hEDS using wearable devices.MethodsWe studied 122 days of biometric device data from 26 individuals, including 35 days highlighted as high gastrointestinal (GI) dysfunction and 48 days as low GI dysfunction. Utilizing wavelet analysis to assess the frequency domains of heart rate signals, we compared participants’ HRV data for high, low, very low (VLF), and ultralow (ULF) frequency domains associated with physiological differences.ResultsWe found a significant difference between the VLF and ULF signals on high-GI symptom days compared with low-symptoms days for 92 and 76% of the signals sampled, respectively.DiscussionOur pilot data show a change in HRV for individuals with hEDS experiencing a flare day for a single-body system. Future research will focus on evaluating the relationship between longitudinal multisystemic symptom severity fluctuations and HRV. |
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| institution | Kabale University |
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| language | English |
| publishDate | 2025-01-01 |
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| spelling | doaj-art-0db51f080dbb4464b70f83d633e2f99e2025-01-15T20:10:26ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-01-011510.3389/fneur.2024.14995821499582Tracking changes in autonomic function by coupled analysis of wavelet-based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile Ehlers–Danlos syndromeSarah A. Mathena0Robert M. Allen1Robert M. Allen2Christina Laukaitis3Christina Laukaitis4Christina Laukaitis5Jennifer G. Andrews6ARID Laboratory, Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ, United StatesARID Laboratory, Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ, United StatesRaytheon Technologies corporation (RTX), Tucson, AZ, United StatesStephens Family Clinical Research Institute, Carle Health, Urbana, IL, United StatesCarle Illinois College of Medicine, University of Illinois, Urbana, IL, United StatesCarl R. Woese Institute for Genomic Biology, University of Illinois, Urbana, IL, United StatesARID Laboratory, Department of Pediatrics, College of Medicine, University of Arizona, Tucson, AZ, United StatesIntroductionPeople with hypermobile Ehlers–Danlos syndrome (hEDS) experience multisystemic dysfunction with varying severity and unpredictability of flare occurrence. Cohort studies suggest that individuals with hEDS have a higher risk for autonomic dysfunction. The gold standard for assessing autonomic function, clinically, is the heart rate variability (HRV) assessment from 24-h Holter monitor electrocardiogram data, but this is expensive and can only be performed in short durations. Since their advent, biometric devices have been a non-invasive method for tracking HRV to assess autonomic function. This study aimed to understand the intra- and inter-individual variability in autonomic function and to associate this variability with gastrointestinal symptoms in individuals with hEDS using wearable devices.MethodsWe studied 122 days of biometric device data from 26 individuals, including 35 days highlighted as high gastrointestinal (GI) dysfunction and 48 days as low GI dysfunction. Utilizing wavelet analysis to assess the frequency domains of heart rate signals, we compared participants’ HRV data for high, low, very low (VLF), and ultralow (ULF) frequency domains associated with physiological differences.ResultsWe found a significant difference between the VLF and ULF signals on high-GI symptom days compared with low-symptoms days for 92 and 76% of the signals sampled, respectively.DiscussionOur pilot data show a change in HRV for individuals with hEDS experiencing a flare day for a single-body system. Future research will focus on evaluating the relationship between longitudinal multisystemic symptom severity fluctuations and HRV.https://www.frontiersin.org/articles/10.3389/fneur.2024.1499582/fullEhlers–Danlos syndromeautonomic dysfunctionheart rate variabilitywaveletgastrointestinalbiometrics |
| spellingShingle | Sarah A. Mathena Robert M. Allen Robert M. Allen Christina Laukaitis Christina Laukaitis Christina Laukaitis Jennifer G. Andrews Tracking changes in autonomic function by coupled analysis of wavelet-based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile Ehlers–Danlos syndrome Frontiers in Neurology Ehlers–Danlos syndrome autonomic dysfunction heart rate variability wavelet gastrointestinal biometrics |
| title | Tracking changes in autonomic function by coupled analysis of wavelet-based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile Ehlers–Danlos syndrome |
| title_full | Tracking changes in autonomic function by coupled analysis of wavelet-based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile Ehlers–Danlos syndrome |
| title_fullStr | Tracking changes in autonomic function by coupled analysis of wavelet-based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile Ehlers–Danlos syndrome |
| title_full_unstemmed | Tracking changes in autonomic function by coupled analysis of wavelet-based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile Ehlers–Danlos syndrome |
| title_short | Tracking changes in autonomic function by coupled analysis of wavelet-based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile Ehlers–Danlos syndrome |
| title_sort | tracking changes in autonomic function by coupled analysis of wavelet based dispersion of heart rate variability and gastrointestinal symptom severity in individuals with hypermobile ehlers danlos syndrome |
| topic | Ehlers–Danlos syndrome autonomic dysfunction heart rate variability wavelet gastrointestinal biometrics |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2024.1499582/full |
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