Understanding thrombosis: the critical role of oxidative stress
Thrombosis, a leading contributor to global health burden, is a complex process involving the interplay of various cell types, including vascular endothelial cells, platelets, and red blood cells. Oxidative stress, characterized by an overproduction of reactive oxygen species (ROS), can significantl...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Hematology |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/16078454.2023.2301633 |
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| _version_ | 1846126623988908032 |
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| author | Peiming Li Xueru Ma Guofei Huang |
| author_facet | Peiming Li Xueru Ma Guofei Huang |
| author_sort | Peiming Li |
| collection | DOAJ |
| description | Thrombosis, a leading contributor to global health burden, is a complex process involving the interplay of various cell types, including vascular endothelial cells, platelets, and red blood cells. Oxidative stress, characterized by an overproduction of reactive oxygen species (ROS), can significantly impair the function of these cells, thus instigating a cascade of events leading to thrombus formation. In this review, we comprehensively explore the role of oxidative stress within these cells, and its mechanistic contribution to thrombogenesis, and the application of oxidative therapy in inhibiting thrombosis. By dissecting the intricacies of oxidative stress and its impact on thrombosis, we underscore its potential as a viable therapeutic target. Therefore, further research in this direction is warranted to enhance our understanding and management of thrombotic disorders. |
| format | Article |
| id | doaj-art-0da0c630ead64fe9a4425b6fd6f5c7de |
| institution | Kabale University |
| issn | 1607-8454 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Hematology |
| spelling | doaj-art-0da0c630ead64fe9a4425b6fd6f5c7de2024-12-12T15:08:53ZengTaylor & Francis GroupHematology1607-84542024-12-0129110.1080/16078454.2023.2301633Understanding thrombosis: the critical role of oxidative stressPeiming Li0Xueru Ma1Guofei Huang2Vascular Surgery, Deyang People’s Hospital, Deyang, People’s Republic of ChinaNeurology Department, Deyang People’s Hospital, Deyang, People’s Republic of ChinaVascular Surgery, Deyang People’s Hospital, Deyang, People’s Republic of ChinaThrombosis, a leading contributor to global health burden, is a complex process involving the interplay of various cell types, including vascular endothelial cells, platelets, and red blood cells. Oxidative stress, characterized by an overproduction of reactive oxygen species (ROS), can significantly impair the function of these cells, thus instigating a cascade of events leading to thrombus formation. In this review, we comprehensively explore the role of oxidative stress within these cells, and its mechanistic contribution to thrombogenesis, and the application of oxidative therapy in inhibiting thrombosis. By dissecting the intricacies of oxidative stress and its impact on thrombosis, we underscore its potential as a viable therapeutic target. Therefore, further research in this direction is warranted to enhance our understanding and management of thrombotic disorders.https://www.tandfonline.com/doi/10.1080/16078454.2023.2301633Thrombosisoxidative stressreactive oxygen speciesendothelial cellplateletsred blood cell |
| spellingShingle | Peiming Li Xueru Ma Guofei Huang Understanding thrombosis: the critical role of oxidative stress Hematology Thrombosis oxidative stress reactive oxygen species endothelial cell platelets red blood cell |
| title | Understanding thrombosis: the critical role of oxidative stress |
| title_full | Understanding thrombosis: the critical role of oxidative stress |
| title_fullStr | Understanding thrombosis: the critical role of oxidative stress |
| title_full_unstemmed | Understanding thrombosis: the critical role of oxidative stress |
| title_short | Understanding thrombosis: the critical role of oxidative stress |
| title_sort | understanding thrombosis the critical role of oxidative stress |
| topic | Thrombosis oxidative stress reactive oxygen species endothelial cell platelets red blood cell |
| url | https://www.tandfonline.com/doi/10.1080/16078454.2023.2301633 |
| work_keys_str_mv | AT peimingli understandingthrombosisthecriticalroleofoxidativestress AT xueruma understandingthrombosisthecriticalroleofoxidativestress AT guofeihuang understandingthrombosisthecriticalroleofoxidativestress |