Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation
Abstract Background There is some evidence of reduced major cardiovascular event (MACE) rates associated with moderate coffee consumption in the general population. However, there is concern about the potential risks of coffee consumption in patients with atrial fibrillation (AF). Therefore, we aime...
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2024-12-01
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| Online Access: | https://doi.org/10.1186/s12916-024-03817-x |
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| author | Vasco Iten Elena Herber Michael Coslovsky Elisa Hennings Rebecca E. Paladini Tobias Reichlin Nicolas Rodondi Andreas S. Müller Annina Stauber Juerg H. Beer Roman Brenner Giulio Conte Richard Kobza Marcello Di Valentino Patricia Chocano Bedoya Freschteh Moradi Tim Sinnecker Leo H. Bonati Michael Kühne Stefan Osswald David Conen Stefanie Aeschbacher Christine S. Zuern on behalf of the Swiss-AF and Beat-AF Investigators |
| author_facet | Vasco Iten Elena Herber Michael Coslovsky Elisa Hennings Rebecca E. Paladini Tobias Reichlin Nicolas Rodondi Andreas S. Müller Annina Stauber Juerg H. Beer Roman Brenner Giulio Conte Richard Kobza Marcello Di Valentino Patricia Chocano Bedoya Freschteh Moradi Tim Sinnecker Leo H. Bonati Michael Kühne Stefan Osswald David Conen Stefanie Aeschbacher Christine S. Zuern on behalf of the Swiss-AF and Beat-AF Investigators |
| author_sort | Vasco Iten |
| collection | DOAJ |
| description | Abstract Background There is some evidence of reduced major cardiovascular event (MACE) rates associated with moderate coffee consumption in the general population. However, there is concern about the potential risks of coffee consumption in patients with atrial fibrillation (AF). Therefore, we aimed to investigate the association between coffee consumption and MACE in AF patients. Methods Data of patients with documented AF enrolled in two large prospective observational multicenter cohort studies (Swiss-AF and Beat-AF) were analyzed. Follow-up information was obtained on a yearly basis. Coffee consumption was categorized into two main groups: “daily” and “not-daily” coffee consumers as well as additional subcategories. The primary endpoint was MACE, defined as a composite of stroke or systemic embolism, myocardial infarction, hospitalization for acute heart failure, and cardiovascular mortality. Secondary endpoints were the individual components of MACE and all-cause mortality. We performed time-updated multivariable adjusted Cox regression analyses to investigate the association between coffee consumption and MACE. Results The incidence rate for MACE was 5.09 per 100 person-years (py) in daily and 7.49 per 100 py in not-daily consumers (median follow-up duration: 4.7 years). After adjustment for pre-selected confounding variables, daily coffee consumption was associated with a 23% lower hazard for MACE compared to not-daily consumption (hazard ratio (HR) (95% confidence interval (CI)) 0.77 (0.66; 0.89)). Patients with moderate coffee consumption (2–3 cups/day) had the lowest hazard for MACE compared to patients with not-daily coffee consumption (HR (95% CI) 0.74 (0.63; 0.87)). Conclusions In a population of AF patients, daily coffee consumption was associated with a reduced risk for MACE, hospitalization for acute heart failure, and all-cause mortality. The results were inconclusive for stroke or systemic embolism, myocardial infarction, and cardiovascular death. In this analysis, we found no evidence of an unfavourable association of daily coffee consumption in AF Patients with adverse outcome events. Trial registration ClinicalTrials.gov Identifier: NCT02105844. |
| format | Article |
| id | doaj-art-0d969f017eab491487dd7bc4c2ee2bc4 |
| institution | Kabale University |
| issn | 1741-7015 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Medicine |
| spelling | doaj-art-0d969f017eab491487dd7bc4c2ee2bc42024-12-22T12:30:40ZengBMCBMC Medicine1741-70152024-12-0122111110.1186/s12916-024-03817-xCoffee consumption and adverse cardiovascular events in patients with atrial fibrillationVasco Iten0Elena Herber1Michael Coslovsky2Elisa Hennings3Rebecca E. Paladini4Tobias Reichlin5Nicolas Rodondi6Andreas S. Müller7Annina Stauber8Juerg H. Beer9Roman Brenner10Giulio Conte11Richard Kobza12Marcello Di Valentino13Patricia Chocano Bedoya14Freschteh Moradi15Tim Sinnecker16Leo H. Bonati17Michael Kühne18Stefan Osswald19David Conen20Stefanie Aeschbacher21Christine S. Zuern22on behalf of the Swiss-AF and Beat-AF InvestigatorsCardiovascular Research Institute Basel, University Hospital Basel, University of BaselCardiovascular Research Institute Basel, University Hospital Basel, University of BaselCardiovascular Research Institute Basel, University Hospital Basel, University of BaselCardiovascular Research Institute Basel, University Hospital Basel, University of BaselCardiovascular Research Institute Basel, University Hospital Basel, University of BaselDepartment of Cardiology, Inselspital, Bern University Hospital, University of BernDepartment of General Internal Medicine, Inselspital, Bern University Hospital, University of BernDepartment of Cardiology, Triemli Hospital ZurichDepartment of Cardiology, Triemli Hospital ZurichDepartment of Medicine, Cantonal Hospital of Baden and Molecular Cardiology, University Hospital of ZurichDepartment of Cardiology, Kantonsspital St. GallenDivision of Cardiology, Cardiocentro Ticino Insitute, Ente Ospedaliero CantonaleDepartment of Cardiology, Kantonsspital LuzernDepartment of CardiologyInstitute of Primary Health Care (BIHAM), University of BernCardiovascular Research Institute Basel, University Hospital Basel, University of BaselDepartment of Biomedical Engineering, University of Basel, Medical Image Analysis Center (MIAC AG)Department of Neurology and Stroke Center, University Hospital Basel, University of BaselCardiovascular Research Institute Basel, University Hospital Basel, University of BaselCardiovascular Research Institute Basel, University Hospital Basel, University of BaselPopulation Health Research Institute, McMaster UniversityCardiovascular Research Institute Basel, University Hospital Basel, University of BaselCardiovascular Research Institute Basel, University Hospital Basel, University of BaselAbstract Background There is some evidence of reduced major cardiovascular event (MACE) rates associated with moderate coffee consumption in the general population. However, there is concern about the potential risks of coffee consumption in patients with atrial fibrillation (AF). Therefore, we aimed to investigate the association between coffee consumption and MACE in AF patients. Methods Data of patients with documented AF enrolled in two large prospective observational multicenter cohort studies (Swiss-AF and Beat-AF) were analyzed. Follow-up information was obtained on a yearly basis. Coffee consumption was categorized into two main groups: “daily” and “not-daily” coffee consumers as well as additional subcategories. The primary endpoint was MACE, defined as a composite of stroke or systemic embolism, myocardial infarction, hospitalization for acute heart failure, and cardiovascular mortality. Secondary endpoints were the individual components of MACE and all-cause mortality. We performed time-updated multivariable adjusted Cox regression analyses to investigate the association between coffee consumption and MACE. Results The incidence rate for MACE was 5.09 per 100 person-years (py) in daily and 7.49 per 100 py in not-daily consumers (median follow-up duration: 4.7 years). After adjustment for pre-selected confounding variables, daily coffee consumption was associated with a 23% lower hazard for MACE compared to not-daily consumption (hazard ratio (HR) (95% confidence interval (CI)) 0.77 (0.66; 0.89)). Patients with moderate coffee consumption (2–3 cups/day) had the lowest hazard for MACE compared to patients with not-daily coffee consumption (HR (95% CI) 0.74 (0.63; 0.87)). Conclusions In a population of AF patients, daily coffee consumption was associated with a reduced risk for MACE, hospitalization for acute heart failure, and all-cause mortality. The results were inconclusive for stroke or systemic embolism, myocardial infarction, and cardiovascular death. In this analysis, we found no evidence of an unfavourable association of daily coffee consumption in AF Patients with adverse outcome events. Trial registration ClinicalTrials.gov Identifier: NCT02105844.https://doi.org/10.1186/s12916-024-03817-xAtrial fibrillationCoffeeCaffeineMACEAll-cause mortalityOutcome events |
| spellingShingle | Vasco Iten Elena Herber Michael Coslovsky Elisa Hennings Rebecca E. Paladini Tobias Reichlin Nicolas Rodondi Andreas S. Müller Annina Stauber Juerg H. Beer Roman Brenner Giulio Conte Richard Kobza Marcello Di Valentino Patricia Chocano Bedoya Freschteh Moradi Tim Sinnecker Leo H. Bonati Michael Kühne Stefan Osswald David Conen Stefanie Aeschbacher Christine S. Zuern on behalf of the Swiss-AF and Beat-AF Investigators Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation BMC Medicine Atrial fibrillation Coffee Caffeine MACE All-cause mortality Outcome events |
| title | Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation |
| title_full | Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation |
| title_fullStr | Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation |
| title_full_unstemmed | Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation |
| title_short | Coffee consumption and adverse cardiovascular events in patients with atrial fibrillation |
| title_sort | coffee consumption and adverse cardiovascular events in patients with atrial fibrillation |
| topic | Atrial fibrillation Coffee Caffeine MACE All-cause mortality Outcome events |
| url | https://doi.org/10.1186/s12916-024-03817-x |
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