Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients

Utility of patient-derived xenografts to evaluate drug sensitivity and select optimal treatments for individual non-small-cell lung cancer patients

Abstract Background Patient-derived xenograft (PDX) is currently considered a preferred preclinical model to evaluate drug sensitivity, explore drug resistance mechanisms, and select individualized treatment regimens. Methods Histopathological examination, immunohistochemistry and whole-exome sequen...

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Main Authors: Xiaoqing Wang, Ju Zhu, Lingling Li, Qilin Zhao, Yutang Huang, Chunjie Wen, Dan Chen, Lanxiang Wu
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Molecular Medicine
Subjects:
Non-small-cell lung cancer
Patient-derived xenografts
Drug sensitivity
Osimertinib resistance
Individualized chemotherapy regimen
Online Access:https://doi.org/10.1186/s10020-024-00934-4
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https://doi.org/10.1186/s10020-024-00934-4

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