Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so
Nitric oxide has been suggested as a contributor to tissue injury in various experimental models of gastrointestinal inflammation. However, there is overwhelming evidence that nitric oxide is one of the most important mediators of mucosal defence, influencing such factors as mucus secretion, mucosal...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
1995-01-01
|
| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/S0962935195000640 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849308701196812288 |
|---|---|
| author | Paul Kubes John L. Wallace |
| author_facet | Paul Kubes John L. Wallace |
| author_sort | Paul Kubes |
| collection | DOAJ |
| description | Nitric oxide has been suggested as a contributor to tissue injury in various experimental models of gastrointestinal inflammation. However, there is overwhelming evidence that nitric oxide is one of the most important mediators of mucosal defence, influencing such factors as mucus secretion, mucosal blood flow, ulcer repair and the activity of a variety of mucosal immunocytes. Nitric oxide has the capacity to down-regulate inflammatory responses in the gastrointestinal tract, to scavenge various free radical species and to protect the mucosa from injury induced by topical irritants. Moreover, questions can be raised regarding the evidence purported to support a role for nitric oxide in producing tissue injury. In this review, we provide an overview of the evidence supporting a role for nitric oxide in protecting the gastrointestinal tract from injury. |
| format | Article |
| id | doaj-art-0d63e74f5c744ab6b6b3aba77a6cdafa |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 1995-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-0d63e74f5c744ab6b6b3aba77a6cdafa2025-08-20T03:54:24ZengWileyMediators of Inflammation0962-93511466-18611995-01-014639740510.1155/S0962935195000640Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't soPaul Kubes0John L. Wallace1Gastrointestinal and Immunology Research Groups, Faculty of Medicine, University of Calgary, Alberta, Calgary, CanadaGastrointestinal and Immunology Research Groups, Faculty of Medicine, University of Calgary, Alberta, Calgary, CanadaNitric oxide has been suggested as a contributor to tissue injury in various experimental models of gastrointestinal inflammation. However, there is overwhelming evidence that nitric oxide is one of the most important mediators of mucosal defence, influencing such factors as mucus secretion, mucosal blood flow, ulcer repair and the activity of a variety of mucosal immunocytes. Nitric oxide has the capacity to down-regulate inflammatory responses in the gastrointestinal tract, to scavenge various free radical species and to protect the mucosa from injury induced by topical irritants. Moreover, questions can be raised regarding the evidence purported to support a role for nitric oxide in producing tissue injury. In this review, we provide an overview of the evidence supporting a role for nitric oxide in protecting the gastrointestinal tract from injury.http://dx.doi.org/10.1155/S0962935195000640 |
| spellingShingle | Paul Kubes John L. Wallace Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so Mediators of Inflammation |
| title | Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so |
| title_full | Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so |
| title_fullStr | Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so |
| title_full_unstemmed | Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so |
| title_short | Nitric oxide as a mediator of gastrointestinal mucosal injury?—Say it ain't so |
| title_sort | nitric oxide as a mediator of gastrointestinal mucosal injury say it ain t so |
| url | http://dx.doi.org/10.1155/S0962935195000640 |
| work_keys_str_mv | AT paulkubes nitricoxideasamediatorofgastrointestinalmucosalinjurysayitaintso AT johnlwallace nitricoxideasamediatorofgastrointestinalmucosalinjurysayitaintso |