Evaluation of Subclinical Atherosclerosis in Patients with Psoriatic Arthritis
Background/Aims: Psoriatic arthritis with peripheral and axial involvement; It is a heterogeneous disease that can cause enthesitis, dactylitis, and nail and skin involvement. The persistence of inflammation in psoriasis leads to comorbidities such as psoriatic arthritis, cardiovascular disease, and...
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| Format: | Article |
| Language: | English |
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Selcuk University Press
2024-04-01
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| Series: | Genel Tıp Dergisi |
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| Online Access: | https://dergipark.org.tr/tr/download/article-file/3280547 |
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| _version_ | 1841562220494848000 |
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| author | Enes Gül İrfan Atik Seda Atik |
| author_facet | Enes Gül İrfan Atik Seda Atik |
| author_sort | Enes Gül |
| collection | DOAJ |
| description | Background/Aims: Psoriatic arthritis with peripheral and axial involvement; It is a heterogeneous disease that can cause enthesitis, dactylitis, and nail and skin involvement. The persistence of inflammation in psoriasis leads to comorbidities such as psoriatic arthritis, cardiovascular disease, and metabolic syndrome. Our study aimed to identify subclinical atherosclerosis in psoriatic arthritis patients without a known risk factor and to prevent possible morbidity and mortality in patients.
Methods: Thirty-three patients with psoriatic arthritis and twenty-five healthy control groups were included in our study. Diabetes mellitus, hypertension, coronary artery disease, diagnosis of hyperlipidemia, body mass index above 30, and smoking were determined as exclusion criteria. The age, gender, duration of the disease, medical treatment used for the disease, high-density lipoprotein, low-density lipoprotein, triglyceride, and total cholesterol values, monocyte-lymphocyte ratio, carotid intima-media thickness measurement results obtained by carotid doppler ultrasonography imaging were recorded.
Results: A comparison was made between the study and control groups in terms of age, triglyceride, high-density lipoprotein, low-density lipoprotein, and monocyte-lymphocyte ratio, and no statistically significant difference was observed. Monocyte and lymphocyte levels were significantly higher in the study group (p<0.05). Carotid intima-media thickness was statistically higher in the study group and this difference was statistically significant (p<0.05).
Conclusions: Patients with psoriatic arthritis have an increased risk of atherosclerosis compared to the healthy population without any risk factors. This awareness will be useful in the follow-up of patients and in taking precautions against morbidities that may develop. |
| format | Article |
| id | doaj-art-0d5bb64188214e81a497eb55470f3d5d |
| institution | Kabale University |
| issn | 2602-3741 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Genel Tıp Dergisi |
| spelling | doaj-art-0d5bb64188214e81a497eb55470f3d5d2025-01-03T01:05:26ZengSelcuk University PressGenel Tıp Dergisi2602-37412024-04-0134218618910.54005/geneltip.1331223154Evaluation of Subclinical Atherosclerosis in Patients with Psoriatic ArthritisEnes Gül0İrfan Atik1Seda Atik2CUMHURIYET UNIVERSITY, SCHOOL OF MEDICINE, MEDICINE PR.CUMHURIYET UNIVERSITY, SCHOOL OF MEDICINE, MEDICINE PR.CUMHURIYET UNIVERSITY, SCHOOL OF MEDICINE, MEDICINE PR.Background/Aims: Psoriatic arthritis with peripheral and axial involvement; It is a heterogeneous disease that can cause enthesitis, dactylitis, and nail and skin involvement. The persistence of inflammation in psoriasis leads to comorbidities such as psoriatic arthritis, cardiovascular disease, and metabolic syndrome. Our study aimed to identify subclinical atherosclerosis in psoriatic arthritis patients without a known risk factor and to prevent possible morbidity and mortality in patients. Methods: Thirty-three patients with psoriatic arthritis and twenty-five healthy control groups were included in our study. Diabetes mellitus, hypertension, coronary artery disease, diagnosis of hyperlipidemia, body mass index above 30, and smoking were determined as exclusion criteria. The age, gender, duration of the disease, medical treatment used for the disease, high-density lipoprotein, low-density lipoprotein, triglyceride, and total cholesterol values, monocyte-lymphocyte ratio, carotid intima-media thickness measurement results obtained by carotid doppler ultrasonography imaging were recorded. Results: A comparison was made between the study and control groups in terms of age, triglyceride, high-density lipoprotein, low-density lipoprotein, and monocyte-lymphocyte ratio, and no statistically significant difference was observed. Monocyte and lymphocyte levels were significantly higher in the study group (p<0.05). Carotid intima-media thickness was statistically higher in the study group and this difference was statistically significant (p<0.05). Conclusions: Patients with psoriatic arthritis have an increased risk of atherosclerosis compared to the healthy population without any risk factors. This awareness will be useful in the follow-up of patients and in taking precautions against morbidities that may develop.https://dergipark.org.tr/tr/download/article-file/3280547psöriatik artritkarotis intima media kalınlığısubklinik aterosklerozultrasonografipsoriatic arthritiscarotid intima-media thicknesssubclinical atherosclerosisultrasonography |
| spellingShingle | Enes Gül İrfan Atik Seda Atik Evaluation of Subclinical Atherosclerosis in Patients with Psoriatic Arthritis Genel Tıp Dergisi psöriatik artrit karotis intima media kalınlığı subklinik ateroskleroz ultrasonografi psoriatic arthritis carotid intima-media thickness subclinical atherosclerosis ultrasonography |
| title | Evaluation of Subclinical Atherosclerosis in Patients with Psoriatic Arthritis |
| title_full | Evaluation of Subclinical Atherosclerosis in Patients with Psoriatic Arthritis |
| title_fullStr | Evaluation of Subclinical Atherosclerosis in Patients with Psoriatic Arthritis |
| title_full_unstemmed | Evaluation of Subclinical Atherosclerosis in Patients with Psoriatic Arthritis |
| title_short | Evaluation of Subclinical Atherosclerosis in Patients with Psoriatic Arthritis |
| title_sort | evaluation of subclinical atherosclerosis in patients with psoriatic arthritis |
| topic | psöriatik artrit karotis intima media kalınlığı subklinik ateroskleroz ultrasonografi psoriatic arthritis carotid intima-media thickness subclinical atherosclerosis ultrasonography |
| url | https://dergipark.org.tr/tr/download/article-file/3280547 |
| work_keys_str_mv | AT enesgul evaluationofsubclinicalatherosclerosisinpatientswithpsoriaticarthritis AT irfanatik evaluationofsubclinicalatherosclerosisinpatientswithpsoriaticarthritis AT sedaatik evaluationofsubclinicalatherosclerosisinpatientswithpsoriaticarthritis |