The role of <sup>18</sup>F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomas
Aim. To determine the diagnostic value of positron emission tomography (PET)/computed tomography (CT) with F-18 fluorodeoxyglucose (18F-FDG) for monitoring the effectiveness and prognosis of lymphoma therapy.Materials and methods. Retrospective data of 18F-FDG PET/CT (before treatment (PET1), after...
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Siberian State Medical University (Tomsk)
2021-07-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/4388 |
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| author | N. G. Chanchikova V. I. Chernov E. A. Dudnikova E. A. Karlova A. S. Savelyeva O. A. Silkina R. V. Zelchan O. D. Bragin A. A. Medvedeva E. V. Berezneeva |
| author_facet | N. G. Chanchikova V. I. Chernov E. A. Dudnikova E. A. Karlova A. S. Savelyeva O. A. Silkina R. V. Zelchan O. D. Bragin A. A. Medvedeva E. V. Berezneeva |
| author_sort | N. G. Chanchikova |
| collection | DOAJ |
| description | Aim. To determine the diagnostic value of positron emission tomography (PET)/computed tomography (CT) with F-18 fluorodeoxyglucose (18F-FDG) for monitoring the effectiveness and prognosis of lymphoma therapy.Materials and methods. Retrospective data of 18F-FDG PET/CT (before treatment (PET1), after two cycles (PET2), and after completion of chemotherapy (PET3)) in 30 people with lymphomas were analyzed.Results. A complete metabolic response in PET2 (PET2–) was observed in 21 patients (70%). In 9 patients in PET2–, a partial metabolic response (6 people), lack of metabolic response (2 people), or metabolic progression (1person) were detected. These patients comprised the PET2+ group.After chemotherapy, a complete metabolic response (PET3–) was diagnosed in 26 patients (87%). This effect was achieved in 21 patients (100%) with PET2– and in 5 patients (66%) with PET2+. Of the 9 patients in the PET2+ group, in 4 (44%) patients, a partial metabolic response or no metabolic response was diagnosed. Further monitoring of these patients showed that progression was diagnosed in 2 cases, and in 2 patients, further treatment resulted in complete remission. A two-year follow-up of patients revealed that remission was observed in 20 (67%) patients. The analysis of the results of PET2 showed that a relapse of the disease was observed in 6 (67%) PET2+ patients and remission was noted in 3 (33%) patients. In PET2– patients, a relapse was diagnosed in 4 (19%) persons, and remission was established in 17 (81%) patients.Conclusion. Early PET/CT with 18F-FDG allows to predict the effect of lymphoma treatment. The method can be recommended for monitoring lymphoma therapy. |
| format | Article |
| id | doaj-art-0d58b28fba034a09976c827f2a801424 |
| institution | Kabale University |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-0d58b28fba034a09976c827f2a8014242025-08-20T04:00:12ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842021-07-0120212012910.20538/1682-0363-2021-2-120-1292789The role of <sup>18</sup>F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomasN. G. Chanchikova0V. I. Chernov1E. A. Dudnikova2E. A. Karlova3A. S. Savelyeva4O. A. Silkina5R. V. Zelchan6O. D. Bragin7A. A. Medvedeva8E. V. Berezneeva9Federal Siberian Research Clinical Center, Federal Medical Biological AgencyCancer Research Institute, Tomsk National Research Medical Center (NRMC) Russian Academy of Sciences; National Research Tomsk Polytechnic University (NR TPU)Cancer Research Institute, Tomsk National Research Medical Center (NRMC) Russian Academy of SciencesFederal Siberian Research Clinical Center, Federal Medical Biological AgencyFederal Siberian Research Clinical Center, Federal Medical Biological AgencyFederal Siberian Research Clinical Center, Federal Medical Biological AgencyCancer Research Institute, Tomsk National Research Medical Center (NRMC) Russian Academy of Sciences; National Research Tomsk Polytechnic University (NR TPU)Cancer Research Institute, Tomsk National Research Medical Center (NRMC) Russian Academy of Sciences; National Research Tomsk Polytechnic University (NR TPU)Cancer Research Institute, Tomsk National Research Medical Center (NRMC) Russian Academy of SciencesNational Research Tomsk Polytechnic University (NR TPU)Aim. To determine the diagnostic value of positron emission tomography (PET)/computed tomography (CT) with F-18 fluorodeoxyglucose (18F-FDG) for monitoring the effectiveness and prognosis of lymphoma therapy.Materials and methods. Retrospective data of 18F-FDG PET/CT (before treatment (PET1), after two cycles (PET2), and after completion of chemotherapy (PET3)) in 30 people with lymphomas were analyzed.Results. A complete metabolic response in PET2 (PET2–) was observed in 21 patients (70%). In 9 patients in PET2–, a partial metabolic response (6 people), lack of metabolic response (2 people), or metabolic progression (1person) were detected. These patients comprised the PET2+ group.After chemotherapy, a complete metabolic response (PET3–) was diagnosed in 26 patients (87%). This effect was achieved in 21 patients (100%) with PET2– and in 5 patients (66%) with PET2+. Of the 9 patients in the PET2+ group, in 4 (44%) patients, a partial metabolic response or no metabolic response was diagnosed. Further monitoring of these patients showed that progression was diagnosed in 2 cases, and in 2 patients, further treatment resulted in complete remission. A two-year follow-up of patients revealed that remission was observed in 20 (67%) patients. The analysis of the results of PET2 showed that a relapse of the disease was observed in 6 (67%) PET2+ patients and remission was noted in 3 (33%) patients. In PET2– patients, a relapse was diagnosed in 4 (19%) persons, and remission was established in 17 (81%) patients.Conclusion. Early PET/CT with 18F-FDG allows to predict the effect of lymphoma treatment. The method can be recommended for monitoring lymphoma therapy.https://bulletin.ssmu.ru/jour/article/view/4388hodgkin’s lymphomanon-hodgkin’s lymphomacomputed tomographypositron emission tomographymonitoring of lymphoma therapyprognosis of lymphoma therapy |
| spellingShingle | N. G. Chanchikova V. I. Chernov E. A. Dudnikova E. A. Karlova A. S. Savelyeva O. A. Silkina R. V. Zelchan O. D. Bragin A. A. Medvedeva E. V. Berezneeva The role of <sup>18</sup>F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomas Бюллетень сибирской медицины hodgkin’s lymphoma non-hodgkin’s lymphoma computed tomography positron emission tomography monitoring of lymphoma therapy prognosis of lymphoma therapy |
| title | The role of <sup>18</sup>F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomas |
| title_full | The role of <sup>18</sup>F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomas |
| title_fullStr | The role of <sup>18</sup>F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomas |
| title_full_unstemmed | The role of <sup>18</sup>F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomas |
| title_short | The role of <sup>18</sup>F-FDG PET/CT in evaluation of therapy effectiveness and prognosis of lymphomas |
| title_sort | role of sup 18 sup f fdg pet ct in evaluation of therapy effectiveness and prognosis of lymphomas |
| topic | hodgkin’s lymphoma non-hodgkin’s lymphoma computed tomography positron emission tomography monitoring of lymphoma therapy prognosis of lymphoma therapy |
| url | https://bulletin.ssmu.ru/jour/article/view/4388 |
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