Increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer: a nationwide cohort study
Abstract Background Given that patients with thyroid cancer experience several metabolic disorders, it is inferred that these patients have an elevated risk of non-alcoholic fatty liver disease (NAFLD). However, large-scale studies on this topic are lacking. This study aimed to elucidate the associa...
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BMC
2025-07-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-14485-2 |
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| author | Young Bin Cho Kyoung Sik Park |
| author_facet | Young Bin Cho Kyoung Sik Park |
| author_sort | Young Bin Cho |
| collection | DOAJ |
| description | Abstract Background Given that patients with thyroid cancer experience several metabolic disorders, it is inferred that these patients have an elevated risk of non-alcoholic fatty liver disease (NAFLD). However, large-scale studies on this topic are lacking. This study aimed to elucidate the association between thyroid cancer and NAFLD. Methods We used data from the Korean National Health Insurance Service Sample Cohort. A total of 1,407 patients with thyroid cancer and 4,221 matched controls were included following the exclusion process and propensity score matching at a ratio of 1:3. We analyzed hazard ratio, risk factors for NAFLD. Results The study revealed an increased risk of NAFLD (HR 2.28; 95% CI 1.69–3.10; P < 0.001) in patients with thyroid cancer. Thyroid cancer patients exhibited a higher risk of NAFLD when they had no regular exercise (HR 2.41; 95% CI 1.75–3.32). Moreover, body mass index (BMI) and levothyroxine dosage have been identified as potential critical factors for the development of NAFLD in patients with thyroid cancer. Conclusion The incidence rate of NAFLD was higher in patients with thyroid cancer than in the controls. Healthcare professionals should consider regular physical activity, BMI, and cumulative levothyroxine dosage when managing patients with thyroid cancer to mitigate the incidence of NAFLD. |
| format | Article |
| id | doaj-art-0d47ebf958ec4f3da8f39bc7e0a6db7c |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | BMC |
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| series | BMC Cancer |
| spelling | doaj-art-0d47ebf958ec4f3da8f39bc7e0a6db7c2025-08-20T03:45:30ZengBMCBMC Cancer1471-24072025-07-0125111010.1186/s12885-025-14485-2Increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer: a nationwide cohort studyYoung Bin Cho0Kyoung Sik Park1Department of Medicine, Graduate School of Konkuk UniversityDepartment of Surgery, Konkuk University Medical CenterAbstract Background Given that patients with thyroid cancer experience several metabolic disorders, it is inferred that these patients have an elevated risk of non-alcoholic fatty liver disease (NAFLD). However, large-scale studies on this topic are lacking. This study aimed to elucidate the association between thyroid cancer and NAFLD. Methods We used data from the Korean National Health Insurance Service Sample Cohort. A total of 1,407 patients with thyroid cancer and 4,221 matched controls were included following the exclusion process and propensity score matching at a ratio of 1:3. We analyzed hazard ratio, risk factors for NAFLD. Results The study revealed an increased risk of NAFLD (HR 2.28; 95% CI 1.69–3.10; P < 0.001) in patients with thyroid cancer. Thyroid cancer patients exhibited a higher risk of NAFLD when they had no regular exercise (HR 2.41; 95% CI 1.75–3.32). Moreover, body mass index (BMI) and levothyroxine dosage have been identified as potential critical factors for the development of NAFLD in patients with thyroid cancer. Conclusion The incidence rate of NAFLD was higher in patients with thyroid cancer than in the controls. Healthcare professionals should consider regular physical activity, BMI, and cumulative levothyroxine dosage when managing patients with thyroid cancer to mitigate the incidence of NAFLD.https://doi.org/10.1186/s12885-025-14485-2Thyroid cancerNonalcoholic fatty liver diseaseTSH suppression |
| spellingShingle | Young Bin Cho Kyoung Sik Park Increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer: a nationwide cohort study BMC Cancer Thyroid cancer Nonalcoholic fatty liver disease TSH suppression |
| title | Increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer: a nationwide cohort study |
| title_full | Increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer: a nationwide cohort study |
| title_fullStr | Increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer: a nationwide cohort study |
| title_full_unstemmed | Increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer: a nationwide cohort study |
| title_short | Increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer: a nationwide cohort study |
| title_sort | increased risk of nonalcoholic fatty liver disease in patients with thyroid cancer a nationwide cohort study |
| topic | Thyroid cancer Nonalcoholic fatty liver disease TSH suppression |
| url | https://doi.org/10.1186/s12885-025-14485-2 |
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