Oligostyrylbenzene Derivatives with Antiparasitic and Antibacterial Activity as Potent G-Quadruplex Ligands

Oligostyrylbenzene Derivatives with Antiparasitic and Antibacterial Activity as Potent G-Quadruplex Ligands

G-quadruplexes (G4s) are non-canonical secondary structures that play a crucial role in the regulation of genetic expression. This study explores the interaction between G4s and a small family of oligostyrylbenzene (OSB) derivatives, characterized by tris(styryl)benzene and tetrastyrylbenzene backbo...

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Bibliographic Details
Main Authors: Manuel Pérez-Soto, Pablo Peñalver, Paloma Muñoz-Báez, Juan Tolosa, Joaquín Calixto García-Martínez, Rubén Cebrián, Juan Carlos Morales
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Molecules
Subjects:
DNA
G-quadruplex
ligands
photophysical properties
antiparasitic
antibiotic
Online Access:https://www.mdpi.com/1420-3049/29/24/5875
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