Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy
<b>Background:</b> Pre-eclampsia (PE) is a serious condition affecting 2–8% of pregnancies worldwide, leading to high maternal and fetal morbidity and mortality. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as potential biomarkers for various pregnancy-related patholo...
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MDPI AG
2024-12-01
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| author | Roman A. Illarionov Anastasia R. Maltseva Olga V. Pachuliia Tatiana B. Postnikova Elena S. Vashukova Anastasiia K. Popova Yulia A. Nasykhova Olesya N. Bespalova Andrey S. Glotov |
| author_facet | Roman A. Illarionov Anastasia R. Maltseva Olga V. Pachuliia Tatiana B. Postnikova Elena S. Vashukova Anastasiia K. Popova Yulia A. Nasykhova Olesya N. Bespalova Andrey S. Glotov |
| author_sort | Roman A. Illarionov |
| collection | DOAJ |
| description | <b>Background:</b> Pre-eclampsia (PE) is a serious condition affecting 2–8% of pregnancies worldwide, leading to high maternal and fetal morbidity and mortality. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as potential biomarkers for various pregnancy-related pathologies, including PE. MiRNAs in plasma and serum have been extensively studied, but urinary miRNAs remain underexplored, especially during early pregnancy. This study aimed to investigate the urinary miRNA expression profiles in women with pre-eclampsia during the first and second trimesters. <b>Materials and Methods:</b> A prospective study was conducted using 48 urine samples from 24 pregnant women (n = 12 pre-eclampsia and n = 12 controls). Urine samples were collected in the first (9–13 weeks) and second (22–24 weeks) trimesters. MiRNA isolation, library preparation, and high-throughput sequencing were performed, followed by differential expression and enrichment analyses. <b>Results:</b> In the first trimester, five miRNAs were dysregulated in PE in comparison with the control group (hsa-miR-184, hsa-miR-203a-3p, hsa-miR-205-5p, hsa-miR-223-3p—downregulated; hsa-miR-1-3p—upregulated). In the second trimester, hsa-miR-205-5p and hsa-miR-223-3p were downregulated, and hsa-miR-9-5p, hsa-miR-1-3p, and hsa-miR-206 were upregulated. <b>Conclusions:</b> Our study identified differentially expressed miRNAs in the urine of pre-eclamptic patients during early pregnancy. These findings suggest that specific urinary miRNAs could serve as non-invasive biomarkers for the early detection and risk assessment of pre-eclampsia. The changes in the level of differential expression of miRNAs during gestation highlight their role in the progression of PE. Further research and validation with a larger cohort are needed to explore their clinical potential for improving maternal and fetal outcomes through early intervention. |
| format | Article |
| id | doaj-art-0d2f06fcdda547bab02ee2bc8b9ff167 |
| institution | Kabale University |
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| language | English |
| publishDate | 2024-12-01 |
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| series | Non-Coding RNA |
| spelling | doaj-art-0d2f06fcdda547bab02ee2bc8b9ff1672024-12-27T14:43:39ZengMDPI AGNon-Coding RNA2311-553X2024-12-011066110.3390/ncrna10060061Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-PregnancyRoman A. Illarionov0Anastasia R. Maltseva1Olga V. Pachuliia2Tatiana B. Postnikova3Elena S. Vashukova4Anastasiia K. Popova5Yulia A. Nasykhova6Olesya N. Bespalova7Andrey S. Glotov8Department of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, RussiaDepartment of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, RussiaDepartment of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, RussiaDepartment of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, RussiaDepartment of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, RussiaDepartment of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, RussiaDepartment of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, RussiaDepartment of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, RussiaDepartment of Genomic Medicine, D.O. Ott Research Institute for Obstetrics, Gynecology, and Reproduction, St. Petersburg 199034, Russia<b>Background:</b> Pre-eclampsia (PE) is a serious condition affecting 2–8% of pregnancies worldwide, leading to high maternal and fetal morbidity and mortality. MicroRNAs (miRNAs), small non-coding RNA molecules, have emerged as potential biomarkers for various pregnancy-related pathologies, including PE. MiRNAs in plasma and serum have been extensively studied, but urinary miRNAs remain underexplored, especially during early pregnancy. This study aimed to investigate the urinary miRNA expression profiles in women with pre-eclampsia during the first and second trimesters. <b>Materials and Methods:</b> A prospective study was conducted using 48 urine samples from 24 pregnant women (n = 12 pre-eclampsia and n = 12 controls). Urine samples were collected in the first (9–13 weeks) and second (22–24 weeks) trimesters. MiRNA isolation, library preparation, and high-throughput sequencing were performed, followed by differential expression and enrichment analyses. <b>Results:</b> In the first trimester, five miRNAs were dysregulated in PE in comparison with the control group (hsa-miR-184, hsa-miR-203a-3p, hsa-miR-205-5p, hsa-miR-223-3p—downregulated; hsa-miR-1-3p—upregulated). In the second trimester, hsa-miR-205-5p and hsa-miR-223-3p were downregulated, and hsa-miR-9-5p, hsa-miR-1-3p, and hsa-miR-206 were upregulated. <b>Conclusions:</b> Our study identified differentially expressed miRNAs in the urine of pre-eclamptic patients during early pregnancy. These findings suggest that specific urinary miRNAs could serve as non-invasive biomarkers for the early detection and risk assessment of pre-eclampsia. The changes in the level of differential expression of miRNAs during gestation highlight their role in the progression of PE. Further research and validation with a larger cohort are needed to explore their clinical potential for improving maternal and fetal outcomes through early intervention.https://www.mdpi.com/2311-553X/10/6/61miRNApregnancyurinepre-eclampsiahigh-throughput sequencing |
| spellingShingle | Roman A. Illarionov Anastasia R. Maltseva Olga V. Pachuliia Tatiana B. Postnikova Elena S. Vashukova Anastasiia K. Popova Yulia A. Nasykhova Olesya N. Bespalova Andrey S. Glotov Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy Non-Coding RNA miRNA pregnancy urine pre-eclampsia high-throughput sequencing |
| title | Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy |
| title_full | Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy |
| title_fullStr | Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy |
| title_full_unstemmed | Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy |
| title_short | Urinary miRNA Expression in Pre-Eclampsia During Early and Mid-Pregnancy |
| title_sort | urinary mirna expression in pre eclampsia during early and mid pregnancy |
| topic | miRNA pregnancy urine pre-eclampsia high-throughput sequencing |
| url | https://www.mdpi.com/2311-553X/10/6/61 |
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