Running modulates primate and rodent visual cortex differently
When mice run, activity in their primary visual cortex (V1) is strongly modulated. This observation has altered conceptions of a brain region assumed to be a passive image processor. Extensive work has followed to dissect the circuits and functions of running-correlated modulation. However, it remai...
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| Format: | Article |
| Language: | English |
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eLife Sciences Publications Ltd
2024-11-01
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| Series: | eLife |
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| Online Access: | https://elifesciences.org/articles/87736 |
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| author | John P Liska Declan P Rowley Trevor Thai Kim Nguyen Jens-Oliver Muthmann Daniel A Butts Jacob Yates Alexander C Huk |
| author_facet | John P Liska Declan P Rowley Trevor Thai Kim Nguyen Jens-Oliver Muthmann Daniel A Butts Jacob Yates Alexander C Huk |
| author_sort | John P Liska |
| collection | DOAJ |
| description | When mice run, activity in their primary visual cortex (V1) is strongly modulated. This observation has altered conceptions of a brain region assumed to be a passive image processor. Extensive work has followed to dissect the circuits and functions of running-correlated modulation. However, it remains unclear whether visual processing in primates might similarly change during locomotion. We therefore measured V1 activity in marmosets while they viewed stimuli on a treadmill. In contrast to mouse, running-correlated modulations of marmoset V1 were small and tended to be slightly suppressive. Population-level analyses revealed trial-to-trial fluctuations of shared gain across V1 in both species, but while strongly correlated with running in mice, gain modulations were smaller and more often negatively correlated with running in marmosets. Thus, population-wide fluctuations of V1 may reflect a common feature of mammalian visual cortical function, but important quantitative differences point to distinct consequences for the relation between vision and action in primates versus rodents. |
| format | Article |
| id | doaj-art-0d2efd7892ef473985bbd766c8f88e9d |
| institution | Kabale University |
| issn | 2050-084X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj-art-0d2efd7892ef473985bbd766c8f88e9d2024-11-19T15:44:24ZengeLife Sciences Publications LtdeLife2050-084X2024-11-011210.7554/eLife.87736Running modulates primate and rodent visual cortex differentlyJohn P Liska0Declan P Rowley1Trevor Thai Kim Nguyen2https://orcid.org/0009-0005-3277-9535Jens-Oliver Muthmann3https://orcid.org/0000-0002-0439-9704Daniel A Butts4https://orcid.org/0000-0002-0158-5317Jacob Yates5https://orcid.org/0000-0001-8322-5982Alexander C Huk6https://orcid.org/0000-0003-1430-6935Departments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United StatesDepartments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United States; Departments of Ophthalmology and Psychiatry & Biobehavioral Sciences, Fuster Laboratory for Cognitive Neuroscience, UCLA, Los Angeles, United StatesDepartments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United StatesDepartments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United StatesDepartment of Biology and Program in Neuroscience and Cognitive Science, University of Maryland, College Park, United StatesHerbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, United StatesDepartments of Neuroscience and Psychology, Center for Perceptual Systems, Institute for Neuroscience, The University of Texas at Austin, Austin, United States; Departments of Ophthalmology and Psychiatry & Biobehavioral Sciences, Fuster Laboratory for Cognitive Neuroscience, UCLA, Los Angeles, United StatesWhen mice run, activity in their primary visual cortex (V1) is strongly modulated. This observation has altered conceptions of a brain region assumed to be a passive image processor. Extensive work has followed to dissect the circuits and functions of running-correlated modulation. However, it remains unclear whether visual processing in primates might similarly change during locomotion. We therefore measured V1 activity in marmosets while they viewed stimuli on a treadmill. In contrast to mouse, running-correlated modulations of marmoset V1 were small and tended to be slightly suppressive. Population-level analyses revealed trial-to-trial fluctuations of shared gain across V1 in both species, but while strongly correlated with running in mice, gain modulations were smaller and more often negatively correlated with running in marmosets. Thus, population-wide fluctuations of V1 may reflect a common feature of mammalian visual cortical function, but important quantitative differences point to distinct consequences for the relation between vision and action in primates versus rodents.https://elifesciences.org/articles/87736Callithrix jacchusV1runningcomparative |
| spellingShingle | John P Liska Declan P Rowley Trevor Thai Kim Nguyen Jens-Oliver Muthmann Daniel A Butts Jacob Yates Alexander C Huk Running modulates primate and rodent visual cortex differently eLife Callithrix jacchus V1 running comparative |
| title | Running modulates primate and rodent visual cortex differently |
| title_full | Running modulates primate and rodent visual cortex differently |
| title_fullStr | Running modulates primate and rodent visual cortex differently |
| title_full_unstemmed | Running modulates primate and rodent visual cortex differently |
| title_short | Running modulates primate and rodent visual cortex differently |
| title_sort | running modulates primate and rodent visual cortex differently |
| topic | Callithrix jacchus V1 running comparative |
| url | https://elifesciences.org/articles/87736 |
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