Conditional ablation of MCU exacerbated cardiac pathology in a genetic arrhythmic model of CPVT

Conditional ablation of MCU exacerbated cardiac pathology in a genetic arrhythmic model of CPVT

Background: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a genetic arrhythmic syndrome caused by mutations in the calcium (Ca2+) release channel ryanodine receptor (RyR2) and its accessory proteins. These mutations make the channel leaky, resulting in Ca2+-dependent arrhythmias. B...

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Bibliographic Details
Main Authors: Arpita Deb, Brian D. Tow, Jie Hao, Branden L. Nguyen, Valeria Gomez, James A. Stewart, Jr, Ashley J. Smuder, Bjorn C. Knollmann, Ying Wang, Bin Liu
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Journal of Molecular and Cellular Cardiology Plus
Subjects:
RyR2 leak
Ca2+-dependent cardiomyopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2772976124000333
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