RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes

RNase 7 and Th cytokines synergistically increase the secretion of interleukin-6 from keratinocytes

Abstract Epidermal keratinocytes are a major source of antimicrobial peptides and proteins. RNase 7 (R7) exhibits antimicrobial and immunomodulatory activities and is upregulated in the lesional skin of atopic dermatitis and psoriasis patients. Here, we performed mRNA microarray analysis to study th...

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Bibliographic Details
Main Authors: Shruti Chopra, Janine Siegl, Verena Kopfnagel, Sylvia Dreyer, Franziska Rademacher, Juliane Lokau, Christoph Garbers, Jürgen Harder, Thomas Werfel, Katinka Döhner
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Scientific Reports
Subjects:
RNase 7
IL-6
IL-24
IL-17
IFN-γ
Inflammatory skin diseases
Online Access:https://doi.org/10.1038/s41598-025-04403-8
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