Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and Therapy
Lipid-coated perfluorocarbon nanodroplets are submicrometer-diameter liquid-filled droplets with proposed applications in molecularly targeted therapeutics and ultrasound (US) imaging. Ultrasonic molecular imaging is unique in that the optimal application of these agents depends not only on the surf...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2006-07-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2006.00019 |
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| _version_ | 1841564516237705216 |
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| author | Paul A. Dayton Shukui Zhao Susannah H. Bloch Pat Schumann Kim Penrose Terry O. Matsunaga Reena Zutshi Alexander Doinikov Katherine W. Ferrara |
| author_facet | Paul A. Dayton Shukui Zhao Susannah H. Bloch Pat Schumann Kim Penrose Terry O. Matsunaga Reena Zutshi Alexander Doinikov Katherine W. Ferrara |
| author_sort | Paul A. Dayton |
| collection | DOAJ |
| description | Lipid-coated perfluorocarbon nanodroplets are submicrometer-diameter liquid-filled droplets with proposed applications in molecularly targeted therapeutics and ultrasound (US) imaging. Ultrasonic molecular imaging is unique in that the optimal application of these agents depends not only on the surface chemistry, but also on the applied US field, which can increase receptor-ligand binding and membrane fusion. Theory and experiments are combined to demonstrate the displacement of perfluorocarbon nanoparticles in the direction of US propagation, where a traveling US wave with a peak pressure on the order of megapascals and frequency in the megahertz range produces a particle translational velocity that is proportional to acoustic intensity and increases with increasing center frequency. Within a vessel with a diameter on the order of hundreds of micrometers or larger, particle velocity on the order of hundreds of micrometers per second is produced and the dominant mechanism for droplet displacement is shown to be bulk fluid streaming. A model for radiation force displacement of particles is developed and demonstrates that effective particle displacement should be feasible in the microvasculature. In a flowing system, acoustic manipulation of targeted droplets increases droplet retention. Additionally, we demonstrate the feasibility of US-enhanced particle internalization and therapeutic delivery. |
| format | Article |
| id | doaj-art-0d0e0ad6762647a3bbc411654198062b |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2006-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-0d0e0ad6762647a3bbc411654198062b2025-01-02T22:37:55ZengSAGE PublishingMolecular Imaging1536-01212006-07-01510.2310/7290.2006.0001910.2310_7290.2006.00019Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and TherapyPaul A. Dayton0Shukui Zhao1Susannah H. Bloch2Pat Schumann3Kim Penrose4Terry O. Matsunaga5Reena Zutshi6Alexander Doinikov7Katherine W. Ferrara8University of California, Davis, USAUniversity of California, Davis, USAUniversity of California, Davis, USAImaRx Therapeutics, Tucson, USAImaRx Therapeutics, Tucson, USAImaRx Therapeutics, Tucson, USAImaRx Therapeutics, Tucson, USABelarus State University, Minsk, BelarusUniversity of California, Davis, USALipid-coated perfluorocarbon nanodroplets are submicrometer-diameter liquid-filled droplets with proposed applications in molecularly targeted therapeutics and ultrasound (US) imaging. Ultrasonic molecular imaging is unique in that the optimal application of these agents depends not only on the surface chemistry, but also on the applied US field, which can increase receptor-ligand binding and membrane fusion. Theory and experiments are combined to demonstrate the displacement of perfluorocarbon nanoparticles in the direction of US propagation, where a traveling US wave with a peak pressure on the order of megapascals and frequency in the megahertz range produces a particle translational velocity that is proportional to acoustic intensity and increases with increasing center frequency. Within a vessel with a diameter on the order of hundreds of micrometers or larger, particle velocity on the order of hundreds of micrometers per second is produced and the dominant mechanism for droplet displacement is shown to be bulk fluid streaming. A model for radiation force displacement of particles is developed and demonstrates that effective particle displacement should be feasible in the microvasculature. In a flowing system, acoustic manipulation of targeted droplets increases droplet retention. Additionally, we demonstrate the feasibility of US-enhanced particle internalization and therapeutic delivery.https://doi.org/10.2310/7290.2006.00019 |
| spellingShingle | Paul A. Dayton Shukui Zhao Susannah H. Bloch Pat Schumann Kim Penrose Terry O. Matsunaga Reena Zutshi Alexander Doinikov Katherine W. Ferrara Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and Therapy Molecular Imaging |
| title | Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and Therapy |
| title_full | Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and Therapy |
| title_fullStr | Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and Therapy |
| title_full_unstemmed | Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and Therapy |
| title_short | Application of Ultrasound to Selectively Localize Nanodroplets for Targeted Imaging and Therapy |
| title_sort | application of ultrasound to selectively localize nanodroplets for targeted imaging and therapy |
| url | https://doi.org/10.2310/7290.2006.00019 |
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