Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver
Abstract Hepatokines play an important role in age-related metabolic disorders for example diabetes. The study҆s aim is to find how resistance training and supplementation of UA affect the levels of Hepatokines in the liver tissue of male Wistar rats that were treated with STZ and were of advanced a...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-01156-2 |
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| author | Zahra Hemati Farsani Mohammad Faramarzi Zeinab Gorgin Karaji Hamid Akbarzadeh Masoumeh Hossein Zadeh |
| author_facet | Zahra Hemati Farsani Mohammad Faramarzi Zeinab Gorgin Karaji Hamid Akbarzadeh Masoumeh Hossein Zadeh |
| author_sort | Zahra Hemati Farsani |
| collection | DOAJ |
| description | Abstract Hepatokines play an important role in age-related metabolic disorders for example diabetes. The study҆s aim is to find how resistance training and supplementation of UA affect the levels of Hepatokines in the liver tissue of male Wistar rats that were treated with STZ and were of advanced age. Twenty-five 21-month-old male rats were randomly assigned to five equal groups: healthy control (HC), diabetic with uric acid supplementation (DU), supplementation plus resistance exercise (DRU), resistance exercise only (DR) and diabetic control (DC).The resistance training protocol was performed for 8 weeks, with 60% of the maximum voluntary contraction capacity (MVCC), climbing the ladder 14–20 times, 5 days a week. Rats were given a combination of high-fat food and 500 mg/kg of UA. Consistent with the results of one-way ANOVA, the decrease in ANGPTL6 in the DU and DR groups compared to the DCgroup is significant (p ≤ 0.05), while the decrease in the DRU group compared to theDU group was not significant (p ≥ 0.05). Fetuin Adecreased significantly (p ≤ 0.05) in the DU group compared to the DC group, but did not change significantly (p ≥ 0.05) in the DR and DRU groups. According to the results of one-way ANOVA, the decrease in FETUB, Hepassocin, LECT2, and Selenoprotein is significant in all groups (p ≤ 0.05). Based on the beneficial effects of resistance training and UA supplementation on glucose metabolism and Hepatokines, it appears that the blend of exercise training and UA supplementation has a more effective therapeutic effect on hepatic Hepatokines in elderly individuals with diabetes. |
| format | Article |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-0cf6a628f99441b1a611ce2b4733fb652025-08-20T04:03:01ZengNature PortfolioScientific Reports2045-23222025-07-0115111210.1038/s41598-025-01156-2Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liverZahra Hemati Farsani0Mohammad Faramarzi1Zeinab Gorgin Karaji2Hamid Akbarzadeh3Masoumeh Hossein Zadeh4Department of Sport Sciences, Ardakan UniversityDepartment of Exercise Physiology, Faculty of Sport Sciences, University of IsfahanDept. of Elementary Education, Farhangian University of Kermanshah ProvinceDept. of Biotechnology, College of Agriculture, Isfahan University of TechnologyDepartment of Sport Physiology, Faculty of Sport Sciences, Shahid Chamran University of AhvazAbstract Hepatokines play an important role in age-related metabolic disorders for example diabetes. The study҆s aim is to find how resistance training and supplementation of UA affect the levels of Hepatokines in the liver tissue of male Wistar rats that were treated with STZ and were of advanced age. Twenty-five 21-month-old male rats were randomly assigned to five equal groups: healthy control (HC), diabetic with uric acid supplementation (DU), supplementation plus resistance exercise (DRU), resistance exercise only (DR) and diabetic control (DC).The resistance training protocol was performed for 8 weeks, with 60% of the maximum voluntary contraction capacity (MVCC), climbing the ladder 14–20 times, 5 days a week. Rats were given a combination of high-fat food and 500 mg/kg of UA. Consistent with the results of one-way ANOVA, the decrease in ANGPTL6 in the DU and DR groups compared to the DCgroup is significant (p ≤ 0.05), while the decrease in the DRU group compared to theDU group was not significant (p ≥ 0.05). Fetuin Adecreased significantly (p ≤ 0.05) in the DU group compared to the DC group, but did not change significantly (p ≥ 0.05) in the DR and DRU groups. According to the results of one-way ANOVA, the decrease in FETUB, Hepassocin, LECT2, and Selenoprotein is significant in all groups (p ≤ 0.05). Based on the beneficial effects of resistance training and UA supplementation on glucose metabolism and Hepatokines, it appears that the blend of exercise training and UA supplementation has a more effective therapeutic effect on hepatic Hepatokines in elderly individuals with diabetes.https://doi.org/10.1038/s41598-025-01156-2Fetuin AANGPTL6DiabetesExerciseFETUBHepassocin |
| spellingShingle | Zahra Hemati Farsani Mohammad Faramarzi Zeinab Gorgin Karaji Hamid Akbarzadeh Masoumeh Hossein Zadeh Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver Scientific Reports Fetuin A ANGPTL6 Diabetes Exercise FETUB Hepassocin |
| title | Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver |
| title_full | Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver |
| title_fullStr | Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver |
| title_full_unstemmed | Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver |
| title_short | Resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver |
| title_sort | resistance training and ursolic acid consumption affect hepatokines in aged diabetic rat liver |
| topic | Fetuin A ANGPTL6 Diabetes Exercise FETUB Hepassocin |
| url | https://doi.org/10.1038/s41598-025-01156-2 |
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