Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment
Despite extensive research in chemotherapy, global cancer concerns persist, exacerbated by the challenge of drug resistance, which imposes economic and medical burdens. Natural compounds, particularly secondary metabolites from medicinal plants, present promising avenues for overcoming cancer drug r...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844024152607 |
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| author | Minh Hien Nguyen Thi Yen Nhi Nguyen Thien Han Nguyen Le Thi Ngoc Tam Le Ngoc Trong Nghia Chau Tu Manh Huy Le Bui Quoc Huy Nguyen |
| author_facet | Minh Hien Nguyen Thi Yen Nhi Nguyen Thien Han Nguyen Le Thi Ngoc Tam Le Ngoc Trong Nghia Chau Tu Manh Huy Le Bui Quoc Huy Nguyen |
| author_sort | Minh Hien Nguyen |
| collection | DOAJ |
| description | Despite extensive research in chemotherapy, global cancer concerns persist, exacerbated by the challenge of drug resistance, which imposes economic and medical burdens. Natural compounds, particularly secondary metabolites from medicinal plants, present promising avenues for overcoming cancer drug resistance due to their diverse structures and essential pharmacological effects. This review provides a comprehensive exploration of cancer cell resistance mechanisms and target actions for reversing resistance and highlights the in vitro and in vivo efficacy of noteworthy alkaloids, flavonoids, and other compounds, emphasizing their potential as therapeutic agents. The molecular properties supporting ligand interactions are thoroughly examined, providing a robust theoretical foundation. The review concludes by discussing methods including quantitative structure-activity relationships and molecular docking, offering insights into screening potential candidates. Current trends in clinical treatment, contributing to a holistic understanding of the multifaceted approaches to address cancer drug resistance are also outlined. |
| format | Article |
| id | doaj-art-0ccd57f7dca94ccf82a32b3a19c1ea1c |
| institution | Kabale University |
| issn | 2405-8440 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj-art-0ccd57f7dca94ccf82a32b3a19c1ea1c2024-11-12T05:20:07ZengElsevierHeliyon2405-84402024-10-011020e39229Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatmentMinh Hien Nguyen0Thi Yen Nhi Nguyen1Thien Han Nguyen Le2Thi Ngoc Tam Le3Ngoc Trong Nghia Chau4Tu Manh Huy Le5Bui Quoc Huy Nguyen6University of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, Viet Nam; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh city, Viet Nam; Corresponding author. University of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, Viet Nam.University of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, Viet Nam; Vietnam National University Ho Chi Minh City, Linh Trung Ward, Thu Duc City, Ho Chi Minh city, Viet Nam; Faculty of Applied Science, Ho Chi Minh City University of Technology, Vietnam National University Ho Chi Minh City, 268 Ly Thuong Kiet Street Ward 14, District 10, Ho Chi Minh City, Viet NamUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, Viet NamUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, Viet NamUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, Viet NamUniversity of Health Sciences, Vietnam National University Ho Chi Minh City, YA1 Administrative Building, Hai Thuong Lan Ong Street, Dong Hoa Ward, Di An City, Binh Duong Province, Viet NamThe University of Danang - VN-UK Institute for Research and Executive Education, 41 Le Duan Street, Hai Chau 1 Ward, Hai Chau District, Danang City, Viet NamDespite extensive research in chemotherapy, global cancer concerns persist, exacerbated by the challenge of drug resistance, which imposes economic and medical burdens. Natural compounds, particularly secondary metabolites from medicinal plants, present promising avenues for overcoming cancer drug resistance due to their diverse structures and essential pharmacological effects. This review provides a comprehensive exploration of cancer cell resistance mechanisms and target actions for reversing resistance and highlights the in vitro and in vivo efficacy of noteworthy alkaloids, flavonoids, and other compounds, emphasizing their potential as therapeutic agents. The molecular properties supporting ligand interactions are thoroughly examined, providing a robust theoretical foundation. The review concludes by discussing methods including quantitative structure-activity relationships and molecular docking, offering insights into screening potential candidates. Current trends in clinical treatment, contributing to a holistic understanding of the multifaceted approaches to address cancer drug resistance are also outlined.http://www.sciencedirect.com/science/article/pii/S2405844024152607Medicinal plantChemotherapyCancer drug resistanceAnticancer |
| spellingShingle | Minh Hien Nguyen Thi Yen Nhi Nguyen Thien Han Nguyen Le Thi Ngoc Tam Le Ngoc Trong Nghia Chau Tu Manh Huy Le Bui Quoc Huy Nguyen Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment Heliyon Medicinal plant Chemotherapy Cancer drug resistance Anticancer |
| title | Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment |
| title_full | Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment |
| title_fullStr | Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment |
| title_full_unstemmed | Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment |
| title_short | Medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment |
| title_sort | medicinal plants as a potential resource for the discovery of novel structures towards cancer drug resistance treatment |
| topic | Medicinal plant Chemotherapy Cancer drug resistance Anticancer |
| url | http://www.sciencedirect.com/science/article/pii/S2405844024152607 |
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