Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration
Abstract Bone regeneration is a complex biological process that relies on the orchestrated interplay of various cellular and molecular events. Bone tissue engineering is currently the most promising method for treating bone regeneration. However, the immunogenicity, stable and cell quantity of seed...
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| Format: | Article |
| Language: | English |
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BMC
2024-11-01
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| Series: | Stem Cell Research & Therapy |
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| Online Access: | https://doi.org/10.1186/s13287-024-04024-4 |
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| author | Li Deng Yang Liu Qian Wu Shuang Lai Qiu Yang Yandong Mu Mingqing Dong |
| author_facet | Li Deng Yang Liu Qian Wu Shuang Lai Qiu Yang Yandong Mu Mingqing Dong |
| author_sort | Li Deng |
| collection | DOAJ |
| description | Abstract Bone regeneration is a complex biological process that relies on the orchestrated interplay of various cellular and molecular events. Bone tissue engineering is currently the most promising method for treating bone regeneration. However, the immunogenicity, stable and cell quantity of seed cells limited their application. Recently, exosomes, which are small extracellular vesicles released by cells, have been found to effectively address these problems and better induce bone regeneration. Meanwhile, a growing line of research has shown the cargos of exosomes may provide effective therapeutic and biomarker tools for bone repair, including miRNA, lncRNA, and proteins. Moreover, engineered scaffolds loaded with exosomes can offer a cell-free bone repair strategy, addressing immunogenicity concerns and providing a more stable functional performance. Herein, we provide a comprehensive summary of the role played by scaffolds loaded with exosomes in bone regeneration, drawing on a systematic analysis of relevant literature available on PubMed, Scopus, and Google Scholar database. |
| format | Article |
| id | doaj-art-0cc38e05d0eb4d8d91c6824001a5e0a1 |
| institution | Kabale University |
| issn | 1757-6512 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj-art-0cc38e05d0eb4d8d91c6824001a5e0a12024-11-10T12:11:18ZengBMCStem Cell Research & Therapy1757-65122024-11-0115111710.1186/s13287-024-04024-4Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regenerationLi Deng0Yang Liu1Qian Wu2Shuang Lai3Qiu Yang4Yandong Mu5Mingqing Dong6Center for Medicine Research and Translation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine)Center for Medicine Research and Translation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine)Center for Medicine Research and Translation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine)Stomatology Department, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaCenter for Medicine Research and Translation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine)Stomatology Department, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of ChinaCenter for Medicine Research and Translation, Chengdu Fifth People’s Hospital (The Second Clinical Medical College, Affiliated Fifth People’s Hospital of Chengdu University of Traditional Chinese Medicine)Abstract Bone regeneration is a complex biological process that relies on the orchestrated interplay of various cellular and molecular events. Bone tissue engineering is currently the most promising method for treating bone regeneration. However, the immunogenicity, stable and cell quantity of seed cells limited their application. Recently, exosomes, which are small extracellular vesicles released by cells, have been found to effectively address these problems and better induce bone regeneration. Meanwhile, a growing line of research has shown the cargos of exosomes may provide effective therapeutic and biomarker tools for bone repair, including miRNA, lncRNA, and proteins. Moreover, engineered scaffolds loaded with exosomes can offer a cell-free bone repair strategy, addressing immunogenicity concerns and providing a more stable functional performance. Herein, we provide a comprehensive summary of the role played by scaffolds loaded with exosomes in bone regeneration, drawing on a systematic analysis of relevant literature available on PubMed, Scopus, and Google Scholar database.https://doi.org/10.1186/s13287-024-04024-4ExosomeOsteogenesisBiomaterialTissue engineering |
| spellingShingle | Li Deng Yang Liu Qian Wu Shuang Lai Qiu Yang Yandong Mu Mingqing Dong Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration Stem Cell Research & Therapy Exosome Osteogenesis Biomaterial Tissue engineering |
| title | Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration |
| title_full | Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration |
| title_fullStr | Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration |
| title_full_unstemmed | Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration |
| title_short | Exosomes to exosome-functionalized scaffolds: a novel approach to stimulate bone regeneration |
| title_sort | exosomes to exosome functionalized scaffolds a novel approach to stimulate bone regeneration |
| topic | Exosome Osteogenesis Biomaterial Tissue engineering |
| url | https://doi.org/10.1186/s13287-024-04024-4 |
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