The Plasmodium falciparum histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in blood-stage parasites

The Plasmodium falciparum histone methyltransferase PfSET10 is dispensable for the regulation of antigenic variation and gene expression in blood-stage parasites

ABSTRACT The malaria parasite Plasmodium falciparum employs antigenic variation of the virulence factor P. falciparum erythrocyte membrane protein 1 (PfEMP1) to escape adaptive immune responses during blood infection. Antigenic variation of PfEMP1 occurs through epigenetic switches in the mutually e...

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Bibliographic Details
Main Authors: Matthias Wyss, Abhishek Kanyal, Igor Niederwieser, Richard Bartfai, Till S. Voss
Format: Article
Language:English
Published: American Society for Microbiology 2024-11-01
Series:mSphere
Subjects:
Plasmodium falciparum
malaria
antigenic variation
histone methyltransferase
PfSET10
RNA-seq
Online Access:https://journals.asm.org/doi/10.1128/msphere.00546-24
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https://journals.asm.org/doi/10.1128/msphere.00546-24

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