Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperatures

Integrating phenomics and genomics is a promising approach to identify genetic factors that confer stress resistance to plants in certain phases. Differently adapted germplasm enables valuable insights into multiple plant stress resilience mechanisms. The dynamic responses of 106 Mediterranean maize...

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Main Authors: Rongli Shi, Ana López-Malvar, Dominic Knoch, Henning Tschiersch, Marc C. Heuermann, Salar Shaaf, Delphine Madur, Rogelio Santiago, Carlotta Balconi, Elisabetta Frascaroli, Sekip Erdal, Carine Palaffre, Alain Charcosset, Pedro Revilla, Thomas Altmann
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Plant Stress
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Online Access:http://www.sciencedirect.com/science/article/pii/S2667064X25002222
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author Rongli Shi
Ana López-Malvar
Dominic Knoch
Henning Tschiersch
Marc C. Heuermann
Salar Shaaf
Delphine Madur
Rogelio Santiago
Carlotta Balconi
Elisabetta Frascaroli
Sekip Erdal
Carine Palaffre
Alain Charcosset
Pedro Revilla
Thomas Altmann
author_facet Rongli Shi
Ana López-Malvar
Dominic Knoch
Henning Tschiersch
Marc C. Heuermann
Salar Shaaf
Delphine Madur
Rogelio Santiago
Carlotta Balconi
Elisabetta Frascaroli
Sekip Erdal
Carine Palaffre
Alain Charcosset
Pedro Revilla
Thomas Altmann
author_sort Rongli Shi
collection DOAJ
description Integrating phenomics and genomics is a promising approach to identify genetic factors that confer stress resistance to plants in certain phases. Differently adapted germplasm enables valuable insights into multiple plant stress resilience mechanisms. The dynamic responses of 106 Mediterranean maize inbred lines to combined drought and high temperature (D-HT) were investigated by high-throughput shoot phenotyping. Two experiments were conducted under control (25/20 °C, 70 % field capacity) and D-HT conditions (35/25 °C, 30 % field capacity). Stress was applied from 18 to 32 days after sowing, followed by recovery under control conditions. The stress treatment resulted in decreased plant height, projected shoot area, estimated shoot volume (ESV), as well as diminished relative growth rates during the vegetative phase. Additionally, photosynthetic parameters decreased significantly under D-HT, but normalized during a recovery phase. Stress indices, namely stress resistance, stress recovery and stress adaptability, were calculated based on ESV. Both, stress resistance and recovery contributed to maize resilience to D-HT, however they appear to be mediated through different processes. Genome-wide association studies (GWAS) were performed to dissect the genetic basis of maize resilience to D-HT-stress. Overall, associations with 201 unique single nucleotide polymorphism (SNP) markers and 89 linked candidate genes were detected. We conducted a detailed temporal analysis of trait development across stress and recovery phases, and evaluated the dynamics of the underlying genetic system. These findings contribute to refining our understanding of multiple plant stress resilience mechanisms in the face of ongoing global climate change and to advance future maize breeding to enhance stress resilience.
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spelling doaj-art-0c82f830c46c4b54bcbd7990c1f7fdf12025-08-23T04:49:37ZengElsevierPlant Stress2667-064X2025-09-011710095410.1016/j.stress.2025.100954Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperaturesRongli Shi0Ana López-Malvar1Dominic Knoch2Henning Tschiersch3Marc C. Heuermann4Salar Shaaf5Delphine Madur6Rogelio Santiago7Carlotta Balconi8Elisabetta Frascaroli9Sekip Erdal10Carine Palaffre11Alain Charcosset12Pedro Revilla13Thomas Altmann14Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, 06466 Seeland, Germany; Corresponding author at: Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), Germany.Leibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, 06466 Seeland, Germany; University of Vigo, As Lagoas Marcosende, Environmental Agro-biology: Soils and Plants Quality 13 (UVIGO), Associated Unit with MBG (CSIC), 36310 Vigo, SpainLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, 06466 Seeland, GermanyLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, 06466 Seeland, GermanyLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, 06466 Seeland, GermanyLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, 06466 Seeland, GermanyUniversity Paris-Saclay, INRAE, CNRS, AgroParisTech, Quantitative Genetics and Evolution (GQE) - Le Moulon, 91190 Gif-Sur-Yvette, FranceMisión Biológica de Galicia, Spanish National Research Council (CSIC), Carballeira 8, 36143 Pontevedra, SpainResearch Centre for Cereal and Industrial Crops (CREA), Via Stezzano, 24, 24126 Bergamo, ItalyDepartment of Agricultural and Food Sciences, University of Bologna, Viale Fanin, 44 - 40127 Bologna, ItalyBati Akdeniz Agricultural Research Institute, Antalya, TürkiyeMaize Experimental Unit, INRAE, 2297 Route de l’INRA, F-40390 Saint-Martin-de-Hinx, FranceUniversity Paris-Saclay, INRAE, CNRS, AgroParisTech, Quantitative Genetics and Evolution (GQE) - Le Moulon, 91190 Gif-Sur-Yvette, FranceMisión Biológica de Galicia, Spanish National Research Council (CSIC), Carballeira 8, 36143 Pontevedra, SpainLeibniz Institute of Plant Genetics and Crop Plant Research (IPK), OT Gatersleben, 06466 Seeland, GermanyIntegrating phenomics and genomics is a promising approach to identify genetic factors that confer stress resistance to plants in certain phases. Differently adapted germplasm enables valuable insights into multiple plant stress resilience mechanisms. The dynamic responses of 106 Mediterranean maize inbred lines to combined drought and high temperature (D-HT) were investigated by high-throughput shoot phenotyping. Two experiments were conducted under control (25/20 °C, 70 % field capacity) and D-HT conditions (35/25 °C, 30 % field capacity). Stress was applied from 18 to 32 days after sowing, followed by recovery under control conditions. The stress treatment resulted in decreased plant height, projected shoot area, estimated shoot volume (ESV), as well as diminished relative growth rates during the vegetative phase. Additionally, photosynthetic parameters decreased significantly under D-HT, but normalized during a recovery phase. Stress indices, namely stress resistance, stress recovery and stress adaptability, were calculated based on ESV. Both, stress resistance and recovery contributed to maize resilience to D-HT, however they appear to be mediated through different processes. Genome-wide association studies (GWAS) were performed to dissect the genetic basis of maize resilience to D-HT-stress. Overall, associations with 201 unique single nucleotide polymorphism (SNP) markers and 89 linked candidate genes were detected. We conducted a detailed temporal analysis of trait development across stress and recovery phases, and evaluated the dynamics of the underlying genetic system. These findings contribute to refining our understanding of multiple plant stress resilience mechanisms in the face of ongoing global climate change and to advance future maize breeding to enhance stress resilience.http://www.sciencedirect.com/science/article/pii/S2667064X25002222Genome-wide association studyPhenomicsGenomicsStress resistanceStress recoveryMaize
spellingShingle Rongli Shi
Ana López-Malvar
Dominic Knoch
Henning Tschiersch
Marc C. Heuermann
Salar Shaaf
Delphine Madur
Rogelio Santiago
Carlotta Balconi
Elisabetta Frascaroli
Sekip Erdal
Carine Palaffre
Alain Charcosset
Pedro Revilla
Thomas Altmann
Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperatures
Plant Stress
Genome-wide association study
Phenomics
Genomics
Stress resistance
Stress recovery
Maize
title Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperatures
title_full Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperatures
title_fullStr Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperatures
title_full_unstemmed Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperatures
title_short Integrating high-throughput phenotyping and genome-wide association analyses to unravel Mediterranean maize resilience to combined drought and high temperatures
title_sort integrating high throughput phenotyping and genome wide association analyses to unravel mediterranean maize resilience to combined drought and high temperatures
topic Genome-wide association study
Phenomics
Genomics
Stress resistance
Stress recovery
Maize
url http://www.sciencedirect.com/science/article/pii/S2667064X25002222
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