Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models

Protein structure and interactions elucidated with in-cell NMR for different cell cycle phases and in 3D human tissue models

Abstract Most of our knowledge of protein structure and function originates from experiments performed with purified proteins resuspended in dilute, buffered solutions. However, most proteins function in crowded intracellular environments with complex compositions. Significant efforts have been made...

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Main Authors: Jan Rynes, Eva Istvankova, Michaela Dzurov Krafcikova, Enrico Luchinat, Letizia Barbieri, Lucia Banci, Kristyna Kamarytova, Tomas Loja, Bohumil Fafilek, Gustavo Rico-Llanos, Pavel Krejci, Libor Macurek, Silvie Foldynova-Trantirkova, Lukas Trantirek
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-025-07607-w
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