Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary
The intestinal epithelium undergoes continuous homeostatic renewal to conduct the digestion and absorption of nutrients. At the same time, the intestinal epithelial barrier separates the host from the intestinal lumen, preventing systemic infection from enteric pathogens. To maintain homeostasis and...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-01-01
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| Series: | Cellular and Molecular Gastroenterology and Hepatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352345X2400153X |
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| _version_ | 1846166101424078848 |
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| author | C. Chris Yun Yiran Han Beth McConnell |
| author_facet | C. Chris Yun Yiran Han Beth McConnell |
| author_sort | C. Chris Yun |
| collection | DOAJ |
| description | The intestinal epithelium undergoes continuous homeostatic renewal to conduct the digestion and absorption of nutrients. At the same time, the intestinal epithelial barrier separates the host from the intestinal lumen, preventing systemic infection from enteric pathogens. To maintain homeostasis and epithelial functionality, stem cells, which reside in the base of intestinal crypts, generate progenitor cells that ultimately differentiate to produce an array of secretory and absorptive cells. Intestinal regeneration is regulated by niche signaling pathways, specifically, Wnt, bone morphogenetic protein, Notch, and epidermal growth factor. In addition, growth factors and other peptides have emerged as potential modulators of intestinal repair and inflammation through their roles in cellular proliferation, differentiation, migration, and survival. Lysophosphatidic acid (LPA) is such a factor that modulates the proliferation, survival, and migration of epithelial cells while also regulating trafficking of immune cells, both of which are important for tissue homeostasis. Perturbation of LPA signaling, however, has been shown to promote cancer and inflammation. This review focuses on the recent advances in LPA-mediated signaling that contribute to physiological and pathophysiological regulation of the gastrointestinal system. |
| format | Article |
| id | doaj-art-0c69c1ed39f4429cb97d53b622b62ad4 |
| institution | Kabale University |
| issn | 2352-345X |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cellular and Molecular Gastroenterology and Hepatology |
| spelling | doaj-art-0c69c1ed39f4429cb97d53b622b62ad42024-11-16T05:11:31ZengElsevierCellular and Molecular Gastroenterology and Hepatology2352-345X2024-01-01186101398Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummaryC. Chris Yun0Yiran Han1Beth McConnell2Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia; Gastroenterology Research, Atlanta Veterans Administration Medical Center, Decatur, Georgia; Correspondence Address correspondence to: Chris Yun, PhD, Division of Digestive Diseases, Emory University School of Medicine, Atlanta, Georgia 30322.Division of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GeorgiaDivision of Digestive Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GeorgiaThe intestinal epithelium undergoes continuous homeostatic renewal to conduct the digestion and absorption of nutrients. At the same time, the intestinal epithelial barrier separates the host from the intestinal lumen, preventing systemic infection from enteric pathogens. To maintain homeostasis and epithelial functionality, stem cells, which reside in the base of intestinal crypts, generate progenitor cells that ultimately differentiate to produce an array of secretory and absorptive cells. Intestinal regeneration is regulated by niche signaling pathways, specifically, Wnt, bone morphogenetic protein, Notch, and epidermal growth factor. In addition, growth factors and other peptides have emerged as potential modulators of intestinal repair and inflammation through their roles in cellular proliferation, differentiation, migration, and survival. Lysophosphatidic acid (LPA) is such a factor that modulates the proliferation, survival, and migration of epithelial cells while also regulating trafficking of immune cells, both of which are important for tissue homeostasis. Perturbation of LPA signaling, however, has been shown to promote cancer and inflammation. This review focuses on the recent advances in LPA-mediated signaling that contribute to physiological and pathophysiological regulation of the gastrointestinal system.http://www.sciencedirect.com/science/article/pii/S2352345X2400153Xlysophosphatidic acidgastrointestinalcancerinflammation |
| spellingShingle | C. Chris Yun Yiran Han Beth McConnell Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary Cellular and Molecular Gastroenterology and Hepatology lysophosphatidic acid gastrointestinal cancer inflammation |
| title | Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary |
| title_full | Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary |
| title_fullStr | Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary |
| title_full_unstemmed | Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary |
| title_short | Lysophosphatidic Acid Signaling in the Gastrointestinal SystemSummary |
| title_sort | lysophosphatidic acid signaling in the gastrointestinal systemsummary |
| topic | lysophosphatidic acid gastrointestinal cancer inflammation |
| url | http://www.sciencedirect.com/science/article/pii/S2352345X2400153X |
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