Impact of GPC3 rs2267531 Polymorphism on Hepatocellular Carcinoma Susceptibility
Objectives: To evaluate the association between the GPC3 rs2267531 polymorphism and hepatocellular carcinoma (HCC) in individuals from Mongolia. Methods: This study included 270 participants, consisting of 110 males and 160 females, with a mean age of 61.0 years (±9.5). Serum samples were collected...
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Mongolian National University of Medical Sciences
2025-03-01
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| Series: | Central Asian Journal of Medical Sciences |
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| Online Access: | https://www.mongoliajol.info/index.php/CAJMS/article/view/4056 |
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| author | Batchimeg Batbaatar Yesukhei Enkhbat Odonchimeg Tuvshiunsaikhan Yundendash Dashzeveg Munkhtsetseg Bat-Erdene Khulan Unurbuyan Nyam-Erdene Narmandakh Uranbileg Ulziisaikhan Batkhishig Munkhjargal Unenbat Gurbadam Ulzmaa Galsan Bilegtsaikhan Tsolmon Munkhbat Batmunkh Munkhbayar Semchin Sarantuya Jav |
| author_facet | Batchimeg Batbaatar Yesukhei Enkhbat Odonchimeg Tuvshiunsaikhan Yundendash Dashzeveg Munkhtsetseg Bat-Erdene Khulan Unurbuyan Nyam-Erdene Narmandakh Uranbileg Ulziisaikhan Batkhishig Munkhjargal Unenbat Gurbadam Ulzmaa Galsan Bilegtsaikhan Tsolmon Munkhbat Batmunkh Munkhbayar Semchin Sarantuya Jav |
| author_sort | Batchimeg Batbaatar |
| collection | DOAJ |
| description | Objectives: To evaluate the association between the GPC3 rs2267531 polymorphism and hepatocellular carcinoma (HCC) in individuals from Mongolia. Methods: This study included 270 participants, consisting of 110 males and 160 females, with a mean age of 61.0 years (±9.5). Serum samples were collected from all participants, who were categorized into three groups: 90 patients with hepatocellular carcinoma (HCC), 90 individuals in the risk group (RG), and 90 healthy controls. The collected samples were analyzed using allele-specific polymerase chain reaction (PCR). Results: No significant differences in genotype and allele frequencies were observed between the HCC group and the risk or control groups. However, the frequency of the GPC3 C allele was significantly higher in females in the HCC group. Additionally, the protective GG genotype of GPC3 was found to have a significantly lower frequency in females in the HCC group. In contrast, HCV-positive individuals exhibited a higher frequency of the GC genotype. Conclusion: The GPC3 C allele frequency is associated with HCC in females, while the heterozygote GC genotype is linked to HCV infection in both genders. These findings suggest that the GPC3 rs2267531 polymorphism may play a role in HCC susceptibility, particularly in relation to gender and HCV status. |
| format | Article |
| id | doaj-art-0c691cc10ed7412d9f604841a2d6f2c5 |
| institution | Kabale University |
| issn | 2413-8681 2414-9772 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Mongolian National University of Medical Sciences |
| record_format | Article |
| series | Central Asian Journal of Medical Sciences |
| spelling | doaj-art-0c691cc10ed7412d9f604841a2d6f2c52025-08-20T03:47:06ZengMongolian National University of Medical SciencesCentral Asian Journal of Medical Sciences2413-86812414-97722025-03-0111111010.24079/CAJMS.2025.01.0014007Impact of GPC3 rs2267531 Polymorphism on Hepatocellular Carcinoma SusceptibilityBatchimeg Batbaatar0https://orcid.org/0000-0003-1273-555XYesukhei Enkhbat1https://orcid.org/0009-0004-5139-4465Odonchimeg Tuvshiunsaikhan2https://orcid.org/0000-0002-0308-5455Yundendash Dashzeveg3https://orcid.org/0009-0003-6891-6656Munkhtsetseg Bat-Erdene4https://orcid.org/0000-0002-0830-5904Khulan Unurbuyan5https://orcid.org/0000-0001-8504-2813Nyam-Erdene Narmandakh6https://orcid.org/0009-0007-0959-6989Uranbileg Ulziisaikhan7https://orcid.org/0000-0002-6281-5366Batkhishig Munkhjargal8https://orcid.org/0000-0001-8844-3145Unenbat Gurbadam9Ulzmaa Galsan10https://orcid.org/0009-0006-6784-0671Bilegtsaikhan Tsolmon11https://orcid.org/0000-0001-5002-6565Munkhbat Batmunkh12https://orcid.org/0000-0002-8664-7483Munkhbayar Semchin13https://orcid.org/0000-0003-0357-9903Sarantuya Jav14https://orcid.org/0000-0002-3032-4490Department of Molecular Biology and Genetics, School of Bio Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia;Institute of Medical Sciences, Ulaanbaatar, MongoliaInstitute of Medical Sciences, Ulaanbaatar, MongoliaInstitute of Medical Sciences, Ulaanbaatar, MongoliaInstitute of Medical Sciences, Ulaanbaatar, MongoliaInstitute of Medical Sciences, Ulaanbaatar, MongoliaInstitute of Medical Sciences, Ulaanbaatar, MongoliaInstitute of Medical Sciences, Ulaanbaatar, MongoliaInstitute of Medical Sciences, Ulaanbaatar, MongoliaNational Cancer Center of Mongolia, Ulaanbaatar, MongoliaThe Third Central Hospital, Ulaanbaatar, MongoliaDivision of Research and International Affairs, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaSchool of Medicine, International University of Health and Welfare, Narita, JapanInstitute of Medical Sciences, Ulaanbaatar, MongoliaDepartment of Molecular Biology and Genetics, School of Bio Medicine, Mongolian National University of Medical Sciences, Ulaanbaatar, MongoliaObjectives: To evaluate the association between the GPC3 rs2267531 polymorphism and hepatocellular carcinoma (HCC) in individuals from Mongolia. Methods: This study included 270 participants, consisting of 110 males and 160 females, with a mean age of 61.0 years (±9.5). Serum samples were collected from all participants, who were categorized into three groups: 90 patients with hepatocellular carcinoma (HCC), 90 individuals in the risk group (RG), and 90 healthy controls. The collected samples were analyzed using allele-specific polymerase chain reaction (PCR). Results: No significant differences in genotype and allele frequencies were observed between the HCC group and the risk or control groups. However, the frequency of the GPC3 C allele was significantly higher in females in the HCC group. Additionally, the protective GG genotype of GPC3 was found to have a significantly lower frequency in females in the HCC group. In contrast, HCV-positive individuals exhibited a higher frequency of the GC genotype. Conclusion: The GPC3 C allele frequency is associated with HCC in females, while the heterozygote GC genotype is linked to HCV infection in both genders. These findings suggest that the GPC3 rs2267531 polymorphism may play a role in HCC susceptibility, particularly in relation to gender and HCV status.https://www.mongoliajol.info/index.php/CAJMS/article/view/4056hccliver cancersnpgenotypehepatitis virus (b,c,d) |
| spellingShingle | Batchimeg Batbaatar Yesukhei Enkhbat Odonchimeg Tuvshiunsaikhan Yundendash Dashzeveg Munkhtsetseg Bat-Erdene Khulan Unurbuyan Nyam-Erdene Narmandakh Uranbileg Ulziisaikhan Batkhishig Munkhjargal Unenbat Gurbadam Ulzmaa Galsan Bilegtsaikhan Tsolmon Munkhbat Batmunkh Munkhbayar Semchin Sarantuya Jav Impact of GPC3 rs2267531 Polymorphism on Hepatocellular Carcinoma Susceptibility Central Asian Journal of Medical Sciences hcc liver cancer snp genotype hepatitis virus (b,c,d) |
| title | Impact of GPC3 rs2267531 Polymorphism on Hepatocellular Carcinoma Susceptibility |
| title_full | Impact of GPC3 rs2267531 Polymorphism on Hepatocellular Carcinoma Susceptibility |
| title_fullStr | Impact of GPC3 rs2267531 Polymorphism on Hepatocellular Carcinoma Susceptibility |
| title_full_unstemmed | Impact of GPC3 rs2267531 Polymorphism on Hepatocellular Carcinoma Susceptibility |
| title_short | Impact of GPC3 rs2267531 Polymorphism on Hepatocellular Carcinoma Susceptibility |
| title_sort | impact of gpc3 rs2267531 polymorphism on hepatocellular carcinoma susceptibility |
| topic | hcc liver cancer snp genotype hepatitis virus (b,c,d) |
| url | https://www.mongoliajol.info/index.php/CAJMS/article/view/4056 |
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