N-acetylcysteine in Kidney Disease: Molecular Mechanisms, Pharmacokinetics, and Clinical Effectiveness

N-acetylcysteine in Kidney Disease: Molecular Mechanisms, Pharmacokinetics, and Clinical Effectiveness

N-acetylcysteine (NAC) has shown beneficial effects in both acute kidney disease and chronic kidney disease (CKD) in preclinical and clinical studies. Different dosage and administration forms of NAC have specific pharmacokinetic properties that determine the temporal pattern of plasma concentration...

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Bibliographic Details
Main Authors: Estefani Y. Hernández-Cruz, Omar E. Aparicio-Trejo, Fadi A. Hammami, Daniel Bar-Shalom, Martin Tepel, Jose Pedraza-Chaverri, Alexandra Scholze
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Kidney International Reports
Subjects:
acute kidney injury
chronic kidney disease
glutathione
mitochondrial function
N-acetylcysteine
pharmacokinetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024924018503
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