Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty
Objective:. While albumin and the weight-standardized hand grip strength (HGS/W) serve as valuable prognostic indicators for cancer patients, their correlation with the prognosis in frail cancer patients remains inadequately explored. This study aimed to investigate the prognostic importance of the...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health - Lippincott Williams Wilkins
2025-06-01
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| Series: | Journal of Nutritional Oncology |
| Online Access: | http://journals.lww.com/10.1097/JN9.0000000000000053 |
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| author | Xiao-Man Xiong Chu-Ying Zhang Hong-Xia Xu Ge-Ge Zhang Saba Fida Jiu-Wei Cui Wei Li Min Weng Kun-Hua Wang Fu-Xiang Zhou Jun-Qiang Chen Xiang-Hua Wu Han-Ping Shi Yan-Li Zhang Chun-Hua Song |
| author_facet | Xiao-Man Xiong Chu-Ying Zhang Hong-Xia Xu Ge-Ge Zhang Saba Fida Jiu-Wei Cui Wei Li Min Weng Kun-Hua Wang Fu-Xiang Zhou Jun-Qiang Chen Xiang-Hua Wu Han-Ping Shi Yan-Li Zhang Chun-Hua Song |
| author_sort | Xiao-Man Xiong |
| collection | DOAJ |
| description | Objective:. While albumin and the weight-standardized hand grip strength (HGS/W) serve as valuable prognostic indicators for cancer patients, their correlation with the prognosis in frail cancer patients remains inadequately explored. This study aimed to investigate the prognostic importance of the albumin level and HGS/W in cancer patients with frailty and to further investigate their combined prognostic value. Moreover, this comprehensive evaluation aimed to facilitate timely intervention and treatment for frail patients.
Methods:. The research enrolled 5,794 cancer patients identified with frailty from a multicenter research database. The diagnosis of frailty was based on the FRAIL scale. An Albumin-HGS/W score was constructed by combining the albumin and HGS/W values. Cox proportional hazard regression was utilized to examine the association between the albumin level and HGS/W and patient outcomes.
Results:. Among these patients, 2,543 were females and 3,251 were males, with a median age of 60.0 years. Optimal stratification based on patient survival revealed the ideal threshold for HGS/W to be 0.48 for males and 0.39 for females, and for albumin to be 38 for both sexes. The fully adjusted model revealed that higher Albumin-HGS/W scores were correlated with a poorer patient prognosis. Notably, an Albumin-HGS/W score of 2 was associated with a higher risk of mortality compared with a score of 0 in the total population (HR: 1.813, 95% CI: 1.580-2.080, P<0.001).
Conclusions:. Low albumin or HGS/W values are associated with low survival in cancer patients with frailty. Elevated Albumin-HGS/W scores were linked to decreased survival rates in cancer patients with frailty. |
| format | Article |
| id | doaj-art-0c5eb75d49e245949cbe45b8a26b4793 |
| institution | Kabale University |
| issn | 2096-2746 2834-5371 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wolters Kluwer Health - Lippincott Williams Wilkins |
| record_format | Article |
| series | Journal of Nutritional Oncology |
| spelling | doaj-art-0c5eb75d49e245949cbe45b8a26b47932025-08-20T04:02:14ZengWolters Kluwer Health - Lippincott Williams WilkinsJournal of Nutritional Oncology2096-27462834-53712025-06-01102566810.1097/JN9.0000000000000053202506000-00004Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailtyXiao-Man Xiong0Chu-Ying Zhang1Hong-Xia Xu2Ge-Ge Zhang3Saba Fida4Jiu-Wei Cui5Wei Li6Min Weng7Kun-Hua Wang8Fu-Xiang Zhou9Jun-Qiang Chen10Xiang-Hua Wu11Han-Ping Shi12Yan-Li Zhang13Chun-Hua Song14 1 The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China 2 Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China 3 Department of Clinical Nutrition, Daping Hospital, Army Medical University, Chongqing 400042, China 2 Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China 2 Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, China 4 Cancer Center of the First Hospital of Jilin University, Changchun 130021, Jilin, China 4 Cancer Center of the First Hospital of Jilin University, Changchun 130021, Jilin, China 5 Department of Clinical Nutrition, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China 6 Department of Gastrointestinal Surgery, Institute of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650032, Yunnan, China 7 Department of Radiation and Medical Oncology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China 8 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China 8 Department of Gastrointestinal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China 9 Department of Gastrointestinal Surgery and Clinical Nutrition, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China 1 The Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China 2 Department of Epidemiology and Statistics, College of Public Health, Zhengzhou University, Zhengzhou 450001, Henan, ChinaObjective:. While albumin and the weight-standardized hand grip strength (HGS/W) serve as valuable prognostic indicators for cancer patients, their correlation with the prognosis in frail cancer patients remains inadequately explored. This study aimed to investigate the prognostic importance of the albumin level and HGS/W in cancer patients with frailty and to further investigate their combined prognostic value. Moreover, this comprehensive evaluation aimed to facilitate timely intervention and treatment for frail patients. Methods:. The research enrolled 5,794 cancer patients identified with frailty from a multicenter research database. The diagnosis of frailty was based on the FRAIL scale. An Albumin-HGS/W score was constructed by combining the albumin and HGS/W values. Cox proportional hazard regression was utilized to examine the association between the albumin level and HGS/W and patient outcomes. Results:. Among these patients, 2,543 were females and 3,251 were males, with a median age of 60.0 years. Optimal stratification based on patient survival revealed the ideal threshold for HGS/W to be 0.48 for males and 0.39 for females, and for albumin to be 38 for both sexes. The fully adjusted model revealed that higher Albumin-HGS/W scores were correlated with a poorer patient prognosis. Notably, an Albumin-HGS/W score of 2 was associated with a higher risk of mortality compared with a score of 0 in the total population (HR: 1.813, 95% CI: 1.580-2.080, P<0.001). Conclusions:. Low albumin or HGS/W values are associated with low survival in cancer patients with frailty. Elevated Albumin-HGS/W scores were linked to decreased survival rates in cancer patients with frailty.http://journals.lww.com/10.1097/JN9.0000000000000053 |
| spellingShingle | Xiao-Man Xiong Chu-Ying Zhang Hong-Xia Xu Ge-Ge Zhang Saba Fida Jiu-Wei Cui Wei Li Min Weng Kun-Hua Wang Fu-Xiang Zhou Jun-Qiang Chen Xiang-Hua Wu Han-Ping Shi Yan-Li Zhang Chun-Hua Song Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty Journal of Nutritional Oncology |
| title | Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty |
| title_full | Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty |
| title_fullStr | Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty |
| title_full_unstemmed | Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty |
| title_short | Effects of albumin and weight-standardized hand grip strength on survival for cancer patients with frailty |
| title_sort | effects of albumin and weight standardized hand grip strength on survival for cancer patients with frailty |
| url | http://journals.lww.com/10.1097/JN9.0000000000000053 |
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