SYNTHESIS OF 1,4-BENZODIAZEPINE THROUGH PHOTOCHEMICAL REACTION OF 3-PHENYL-3,6-DIHYDRO-[1,2]DIOXINE WITH ETHYLENDIAMINE
Synthesis of 1,4-Benzodiazepine via reaction of ethylendiamine with 3-phenyl-1,2-dioxine has been carried out. The first step of this experiment was conversion of triphenyl phosphine to triphenyl metyl phosphine iodide which was then used to form phenyl butadiene from cinnamaldehyde. The synthesis o...
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| Format: | Article |
| Language: | English |
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Universitas Syiah kuala
2013-06-01
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| Series: | Chimica Didactica Acta |
| Online Access: | https://jurnal.usk.ac.id/JCD/article/view/2118 |
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| author | Muhammad Nazar |
| author_facet | Muhammad Nazar |
| author_sort | Muhammad Nazar |
| collection | DOAJ |
| description | Synthesis of 1,4-Benzodiazepine via reaction of ethylendiamine with 3-phenyl-1,2-dioxine has been carried out. The first step of this experiment was conversion of triphenyl phosphine to triphenyl metyl phosphine iodide which was then used to form phenyl butadiene from cinnamaldehyde. The synthesis of phenyl dioxine was done via photochemical reaction of phenyl butadiene with oxygen gas in the presence of tetraphenyl posphene. The coupling reaction between phenyl phosphine and ethylendiamine was carried out under atmospheric pressure at room temperature. All steps of these reactions were confirmed using TLC with appropriate eluents and the resulting compounds were purified using column chromatography. In addition, all products structure including phenyl dioxine and 1,4-benzodiazepine were determined using HNMR. |
| format | Article |
| id | doaj-art-0c58fd37670948ad8924ea03e96ccee0 |
| institution | Kabale University |
| issn | 2338-4522 2809-6789 |
| language | English |
| publishDate | 2013-06-01 |
| publisher | Universitas Syiah kuala |
| record_format | Article |
| series | Chimica Didactica Acta |
| spelling | doaj-art-0c58fd37670948ad8924ea03e96ccee02024-11-28T23:05:45ZengUniversitas Syiah kualaChimica Didactica Acta2338-45222809-67892013-06-01112025SYNTHESIS OF 1,4-BENZODIAZEPINE THROUGH PHOTOCHEMICAL REACTION OF 3-PHENYL-3,6-DIHYDRO-[1,2]DIOXINE WITH ETHYLENDIAMINEMuhammad Nazar0Prodi Pendidikan Kimia, FKIP Unsyiah, Darussalam, Banda Aceh 23111Synthesis of 1,4-Benzodiazepine via reaction of ethylendiamine with 3-phenyl-1,2-dioxine has been carried out. The first step of this experiment was conversion of triphenyl phosphine to triphenyl metyl phosphine iodide which was then used to form phenyl butadiene from cinnamaldehyde. The synthesis of phenyl dioxine was done via photochemical reaction of phenyl butadiene with oxygen gas in the presence of tetraphenyl posphene. The coupling reaction between phenyl phosphine and ethylendiamine was carried out under atmospheric pressure at room temperature. All steps of these reactions were confirmed using TLC with appropriate eluents and the resulting compounds were purified using column chromatography. In addition, all products structure including phenyl dioxine and 1,4-benzodiazepine were determined using HNMR.https://jurnal.usk.ac.id/JCD/article/view/2118 |
| spellingShingle | Muhammad Nazar SYNTHESIS OF 1,4-BENZODIAZEPINE THROUGH PHOTOCHEMICAL REACTION OF 3-PHENYL-3,6-DIHYDRO-[1,2]DIOXINE WITH ETHYLENDIAMINE Chimica Didactica Acta |
| title | SYNTHESIS OF 1,4-BENZODIAZEPINE THROUGH PHOTOCHEMICAL REACTION OF 3-PHENYL-3,6-DIHYDRO-[1,2]DIOXINE WITH ETHYLENDIAMINE |
| title_full | SYNTHESIS OF 1,4-BENZODIAZEPINE THROUGH PHOTOCHEMICAL REACTION OF 3-PHENYL-3,6-DIHYDRO-[1,2]DIOXINE WITH ETHYLENDIAMINE |
| title_fullStr | SYNTHESIS OF 1,4-BENZODIAZEPINE THROUGH PHOTOCHEMICAL REACTION OF 3-PHENYL-3,6-DIHYDRO-[1,2]DIOXINE WITH ETHYLENDIAMINE |
| title_full_unstemmed | SYNTHESIS OF 1,4-BENZODIAZEPINE THROUGH PHOTOCHEMICAL REACTION OF 3-PHENYL-3,6-DIHYDRO-[1,2]DIOXINE WITH ETHYLENDIAMINE |
| title_short | SYNTHESIS OF 1,4-BENZODIAZEPINE THROUGH PHOTOCHEMICAL REACTION OF 3-PHENYL-3,6-DIHYDRO-[1,2]DIOXINE WITH ETHYLENDIAMINE |
| title_sort | synthesis of 1 4 benzodiazepine through photochemical reaction of 3 phenyl 3 6 dihydro 1 2 dioxine with ethylendiamine |
| url | https://jurnal.usk.ac.id/JCD/article/view/2118 |
| work_keys_str_mv | AT muhammadnazar synthesisof14benzodiazepinethroughphotochemicalreactionof3phenyl36dihydro12dioxinewithethylendiamine |