Basal-like subtype of esophageal adenocarcinoma and it’s morphological, molecular and clinical characteristics

Basal-like subtype of esophageal adenocarcinoma and it’s morphological, molecular and clinical characteristics

Abstract Esophageal adenocarcinoma (EAC) and squamous cell carcinoma are the two main tumor types of the esophagus, each with distinct morphological and molecular features. While mixed adeno-squamous carcinomas are recognized, it remains unclear whether a basal-like subtype—known from breast and pan...

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Bibliographic Details
Main Authors: Su Ir Lyu, Caroline Fretter, Axel M. Hillmer, Bastian Grothey, Sascha Hoppe, Adrian Georg Simon, Thomas Zander, Karl Knipper, Wolfgang Schroeder, Christiane J. Bruns, Alexander Quaas
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Esophageal adenocarcinoma
Cytokeratin 5
Cytokeratin 6
Basal-like subtype
Poor prognosis
Online Access:https://doi.org/10.1038/s41598-025-08721-9
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