Clinical-scale, modular manufacturing of tumor-reactive TILs using a closed and automated culture system

Clinical-scale, modular manufacturing of tumor-reactive TILs using a closed and automated culture system

Recent studies have revealed the potential of tumor-infiltrating lymphocytes (TILs) to treat solid tumors effectively and safely. However, the translation of TIL therapy for patients is still hampered by non-standardized and laborious manufacturing procedures that are expensive and produce highly va...

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Bibliographic Details
Main Authors: Christina Völzke, Lisa Ehrhardt, Laura Fischer, Peter Maul, Carina Wenzel, Arina Riabinska, Elvira Criado-Moronati, Mike Dienstbier, Jessica Hassel, Danmei Zhang, John B. Haanen, Rupert Handgretinger, Ian R. Hardy, Bianca Heemskerk, Andrzej Dzionek
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
tumor reactive T cells
CD137
TILs
CliniMACS Prodigy
REP
GMP compliant cell manufacturing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1483254/full
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