The role of neuroinflammation in cerebral amyloid angiopathy
Summary: Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease characterized by vascular amyloid-β (Aβ) deposition. CAA is often seen in the brains of elderly individuals and in a majority of patients with Alzheimer's disease. The molecular pathways triggered by vascular Aβ, causing ve...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | EBioMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352396424005024 |
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| author | Hilde van den Brink Sabine Voigt Mariel Kozberg Ellis S. van Etten |
| author_facet | Hilde van den Brink Sabine Voigt Mariel Kozberg Ellis S. van Etten |
| author_sort | Hilde van den Brink |
| collection | DOAJ |
| description | Summary: Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease characterized by vascular amyloid-β (Aβ) deposition. CAA is often seen in the brains of elderly individuals and in a majority of patients with Alzheimer's disease. The molecular pathways triggered by vascular Aβ, causing vessel wall breakdown and ultimately leading to intracerebral haemorrhage and cognitive decline, remain poorly understood. The occurrence of CAA-related inflammation (CAA-ri) and Amyloid-Related Imaging Abnormalities (ARIA) have sparked interest for a role of neuroinflammation in CAA pathogenesis. This review discusses prior studies of neuroinflammation in CAA and outlines potential future research directions targeting candidates such as matrix metalloproteinases, complement activation, microglial activation, reactive astrocytes and parenchymal border macrophages. Understanding the role of neuroinflammation in CAA pathogenesis could help identify new therapeutic strategies. |
| format | Article |
| id | doaj-art-0c422e16a8ad4d53bfc7db15a738032a |
| institution | Kabale University |
| issn | 2352-3964 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EBioMedicine |
| spelling | doaj-art-0c422e16a8ad4d53bfc7db15a738032a2024-11-29T06:23:56ZengElsevierEBioMedicine2352-39642024-12-01110105466The role of neuroinflammation in cerebral amyloid angiopathyHilde van den Brink0Sabine Voigt1Mariel Kozberg2Ellis S. van Etten3J. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USADepartment of Neurology, Leiden University Medical Centre, Leiden, the Netherlands; Department of Radiology, Leiden University Medical Centre, Leiden, the NetherlandsJ. Philip Kistler Stroke Research Center, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USADepartment of Neurology, Leiden University Medical Centre, Leiden, the Netherlands; Corresponding author. Albinusdreef 2, 2300, RC, Leiden, the Netherlands.Summary: Cerebral amyloid angiopathy (CAA) is a cerebrovascular disease characterized by vascular amyloid-β (Aβ) deposition. CAA is often seen in the brains of elderly individuals and in a majority of patients with Alzheimer's disease. The molecular pathways triggered by vascular Aβ, causing vessel wall breakdown and ultimately leading to intracerebral haemorrhage and cognitive decline, remain poorly understood. The occurrence of CAA-related inflammation (CAA-ri) and Amyloid-Related Imaging Abnormalities (ARIA) have sparked interest for a role of neuroinflammation in CAA pathogenesis. This review discusses prior studies of neuroinflammation in CAA and outlines potential future research directions targeting candidates such as matrix metalloproteinases, complement activation, microglial activation, reactive astrocytes and parenchymal border macrophages. Understanding the role of neuroinflammation in CAA pathogenesis could help identify new therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S2352396424005024Cerebral amyloid angiopathyCerebral amyloid angiopathy-related inflammationNeuroinflammationAmyloid-βARIA |
| spellingShingle | Hilde van den Brink Sabine Voigt Mariel Kozberg Ellis S. van Etten The role of neuroinflammation in cerebral amyloid angiopathy EBioMedicine Cerebral amyloid angiopathy Cerebral amyloid angiopathy-related inflammation Neuroinflammation Amyloid-β ARIA |
| title | The role of neuroinflammation in cerebral amyloid angiopathy |
| title_full | The role of neuroinflammation in cerebral amyloid angiopathy |
| title_fullStr | The role of neuroinflammation in cerebral amyloid angiopathy |
| title_full_unstemmed | The role of neuroinflammation in cerebral amyloid angiopathy |
| title_short | The role of neuroinflammation in cerebral amyloid angiopathy |
| title_sort | role of neuroinflammation in cerebral amyloid angiopathy |
| topic | Cerebral amyloid angiopathy Cerebral amyloid angiopathy-related inflammation Neuroinflammation Amyloid-β ARIA |
| url | http://www.sciencedirect.com/science/article/pii/S2352396424005024 |
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