Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials
The efficacy of cell therapy is compromised by the suboptimal survival and function of transplanted cells, which can be partly attributed to uncontrolled immunomodulation. To address this issue, the dual role of biomaterials in assisting immune activation and evasion can be used to fine-tune immune...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-12-01
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| Series: | EngMedicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2950489924000381 |
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| author | Jia'nan Zeng Yuhong Jin Yanxiao Ao Wenjing Li Kaini Liang Haoke Chen Yi Long Yanan Du |
| author_facet | Jia'nan Zeng Yuhong Jin Yanxiao Ao Wenjing Li Kaini Liang Haoke Chen Yi Long Yanan Du |
| author_sort | Jia'nan Zeng |
| collection | DOAJ |
| description | The efficacy of cell therapy is compromised by the suboptimal survival and function of transplanted cells, which can be partly attributed to uncontrolled immunomodulation. To address this issue, the dual role of biomaterials in assisting immune activation and evasion can be used to fine-tune immune responses and improve the efficacy and safety of cell therapy. Herein, we summarize different methods used to engineer therapeutic cells with biomaterials across multiple spatial scales and review how biomaterials assist in immune activation or evasion in cell therapy based on a discussion of the effects of biomaterials on endogenous immune cells. We also discuss the appealing features of biomaterials that polarize immune responses toward type 1 or type 2 immunity. In future studies, the biophysical and biochemical properties of biomaterials could be better leveraged for immunomodulatory purposes to fuel prominent improvements in cell therapy, and the relevant regulatory mechanisms should be investigated in a more systematic and in-depth manner. |
| format | Article |
| id | doaj-art-0c3842b3d6c14b5f99c7b145515f048b |
| institution | Kabale University |
| issn | 2950-4899 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | EngMedicine |
| spelling | doaj-art-0c3842b3d6c14b5f99c7b145515f048b2025-01-11T06:42:29ZengElsevierEngMedicine2950-48992024-12-0113100038Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterialsJia'nan Zeng0Yuhong Jin1Yanxiao Ao2Wenjing Li3Kaini Liang4Haoke Chen5Yi Long6Yanan Du7School of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaSchool of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaSchool of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaSchool of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaSchool of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaSchool of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaSchool of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaCorresponding author. School of Biomedical Engineering, Tsinghua University, Beijing, 100084, China.; School of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, Tsinghua University, Beijing, 100084, ChinaThe efficacy of cell therapy is compromised by the suboptimal survival and function of transplanted cells, which can be partly attributed to uncontrolled immunomodulation. To address this issue, the dual role of biomaterials in assisting immune activation and evasion can be used to fine-tune immune responses and improve the efficacy and safety of cell therapy. Herein, we summarize different methods used to engineer therapeutic cells with biomaterials across multiple spatial scales and review how biomaterials assist in immune activation or evasion in cell therapy based on a discussion of the effects of biomaterials on endogenous immune cells. We also discuss the appealing features of biomaterials that polarize immune responses toward type 1 or type 2 immunity. In future studies, the biophysical and biochemical properties of biomaterials could be better leveraged for immunomodulatory purposes to fuel prominent improvements in cell therapy, and the relevant regulatory mechanisms should be investigated in a more systematic and in-depth manner.http://www.sciencedirect.com/science/article/pii/S2950489924000381Multi-scale biomaterialsImmune activationImmune evasionCell therapy |
| spellingShingle | Jia'nan Zeng Yuhong Jin Yanxiao Ao Wenjing Li Kaini Liang Haoke Chen Yi Long Yanan Du Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials EngMedicine Multi-scale biomaterials Immune activation Immune evasion Cell therapy |
| title | Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials |
| title_full | Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials |
| title_fullStr | Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials |
| title_full_unstemmed | Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials |
| title_short | Modulating immune responses for enhanced cell therapies: The dual role of multi-scale biomaterials |
| title_sort | modulating immune responses for enhanced cell therapies the dual role of multi scale biomaterials |
| topic | Multi-scale biomaterials Immune activation Immune evasion Cell therapy |
| url | http://www.sciencedirect.com/science/article/pii/S2950489924000381 |
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