Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational study
ObjectiveThe study aimed to observe the quantity of platelet aggregation in the hepatic tissue of patients with metabolic-associated fatty liver disease (MAFLD) and its relationship with hepatic inflammation, fibrosis, and fatty degeneration.MethodsClinical data of 55 patients with MAFLD and 25 pati...
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1503090/full |
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| author | Rongshan Fan Yandong Li Zeng Du |
| author_facet | Rongshan Fan Yandong Li Zeng Du |
| author_sort | Rongshan Fan |
| collection | DOAJ |
| description | ObjectiveThe study aimed to observe the quantity of platelet aggregation in the hepatic tissue of patients with metabolic-associated fatty liver disease (MAFLD) and its relationship with hepatic inflammation, fibrosis, and fatty degeneration.MethodsClinical data of 55 patients with MAFLD and 25 patients without MAFLD, admitted to the Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from December 2020 to May 2022, were retrospectively analyzed. Liver tissue obtained by liver biopsy underwent routine pathological examination. Immunohistochemical staining with CD63 antibody was performed to label platelets in the liver tissue. Clinical, liver pathology, and immunohistochemical staining data of the study subjects were statistically analyzed using unpaired t-test.ResultsThe quantity of platelet aggregation in the hepatic tissue was higher in MAFLD patients than in non-MAFLD patients and was related to the degree of hepatic inflammation but not to the degree of hepatic fibrosis or fatty degeneration.ConclusionThe quantity of platelet aggregation in hepatic tissue was increased in patients with MAFLD and was related to the degree of hepatic inflammation, |
| format | Article |
| id | doaj-art-0c3612bac7624233945e33ced3634943 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-0c3612bac7624233945e33ced36349432025-01-06T06:59:38ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.15030901503090Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational studyRongshan Fan0Yandong Li1Zeng Du2Department of Hepatology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, Guangdong, ChinaDepartment of Pathology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, Guangdong, ChinaDepartment of Hepatology, Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine, Shenzhen, Guangdong, ChinaObjectiveThe study aimed to observe the quantity of platelet aggregation in the hepatic tissue of patients with metabolic-associated fatty liver disease (MAFLD) and its relationship with hepatic inflammation, fibrosis, and fatty degeneration.MethodsClinical data of 55 patients with MAFLD and 25 patients without MAFLD, admitted to the Shenzhen Hospital of Integrated Traditional Chinese and Western Medicine from December 2020 to May 2022, were retrospectively analyzed. Liver tissue obtained by liver biopsy underwent routine pathological examination. Immunohistochemical staining with CD63 antibody was performed to label platelets in the liver tissue. Clinical, liver pathology, and immunohistochemical staining data of the study subjects were statistically analyzed using unpaired t-test.ResultsThe quantity of platelet aggregation in the hepatic tissue was higher in MAFLD patients than in non-MAFLD patients and was related to the degree of hepatic inflammation but not to the degree of hepatic fibrosis or fatty degeneration.ConclusionThe quantity of platelet aggregation in hepatic tissue was increased in patients with MAFLD and was related to the degree of hepatic inflammation,https://www.frontiersin.org/articles/10.3389/fmed.2024.1503090/fullmetabolic-associated fatty liver diseasehepatic tissueplateletaggregationhepatic inflammation |
| spellingShingle | Rongshan Fan Yandong Li Zeng Du Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational study Frontiers in Medicine metabolic-associated fatty liver disease hepatic tissue platelet aggregation hepatic inflammation |
| title | Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational study |
| title_full | Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational study |
| title_fullStr | Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational study |
| title_full_unstemmed | Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational study |
| title_short | Increased platelet aggregation in hepatic tissue of metabolic-associated fatty liver disease—an observational study |
| title_sort | increased platelet aggregation in hepatic tissue of metabolic associated fatty liver disease an observational study |
| topic | metabolic-associated fatty liver disease hepatic tissue platelet aggregation hepatic inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1503090/full |
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